Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan

Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan

[Rhonda]: Hello, everyone, today I’m sitting
with my friend Ray Cronise. Ray is a former NASA scientist and he is the
co-founder of Zero Gravity. Ray is known for popularizing using mild cold
stress as a tool for weight loss. And he recently did something completely crazy. He has just completed a 21-day medically-supervised
water fast. So, what’s up, Ray? How’s it going? [Ray]: Well, technically, I’m not done because
I still haven’t eaten. This is day 23. I did some other tests at the end, but hopefully
tomorrow or maybe the next day. So I feel so good. I don’t know if I ever have to eat again,
right? This is dietary restriction, right? [Rhonda]: Like, to the extreme, I mean, this
is… [Ray]: To the extreme… Yeah, and you know, there’s a lot of misconceptions. People believe that it’s much more draconian
than it is. And it is socially extreme but it’s probably
not biologically extreme. You know, we can imagine that in our evolutionary
past, there are periods of days or weeks that we didn’t have food and the fact that I feel
perfectly normal, that we had some conversations earlier there are some things that slowed
down a little bit. It’s not like you can do everything and words
don’t come exactly as quickly, but for the most part, it doesn’t feel any different than
day 1. And I think one of the reasons I adapt so
quickly is because I mostly lived a dietary restriction lifestyle when I’m not doing this. But, anyway, it’s interesting that you don’t
feel hunger, I don’t have headaches, I don’t feel tired, you know. I just feel like normal me. It’s just that food just isn’t on the thing
to do. So, for us Type As that love to do stuff,
you just work and do your thing and you don’t have to stop to eat. [Rhonda]: What instigated you just to try
out not eating for 21 days and what’s your… [Ray]: Yeah. So, going back part of my own personal problems
was I had gained 80 pounds during the time period of when I was at NASA and leaving NASA
and the company I had between there for about eight years. And, yeah, I was type 2 diabetic, basically,
I had high cholesterol, I had issues. I lost my weight doing the cold stress and
everybody has read my story on that. You know, it’s in Tim Ferriss’ 4-Hour Body
and TedMed Talk out there. But even when I lost weight, all those things
still didn’t fit. So, I actually had to start looking into diet
and I was exercising and I was doing the sort of a body-life plan, six meals a day, cardio
alternating with upper and lower body six workouts a week. So, it wasn’t like I wasn’t doing what they
said, but it didn’t fix the problems I had. So, as I started digging deeper, about that
time the bow wave of press came with Tim’s book and, of course, everybody looked at ice
baths because Tim, in a chapter, his self-limits that he put in are all about ice baths. And of course, that’s not what I was doing. I did some extreme stuff in the beginning
to sort of understand, but I wasn’t focused on the ice baths. I was focused on just exposing body to mild
cold all the time. You know, I used to say, “Gloves before sweater
makes you look better.” You know, just always making your body burn
just a little bit more calories. And so, in doing that and getting out there,
everybody threw the BS flag. They’re like, “You really didn’t lose weight
that way. The cold you burn more calories.” They used to say, and you can find these articles,
they used to say, “You burn more calories getting hot.” And that’s just simply not true. But then, it was said. And so, then started the myths. And because of the blog and people having
questions, and I constantly get inundated with protein, carbs and fat, I want to know
how the calorie works. So, fast forward a couple of years, I bought
an indirect calorimeter. I had it in the lab, built next to my kitchen. And I just started repeating all the classical
experiments. Well, there’s this whole body of literature
that was done on fasting and it’s fascinating. And, not only as a medical modality that they
were actually getting better. Things that get better at the facility on
here. People are lowering their blood pressure dramatically,
dealing with diabetes, dealing with eczema. You know, I had a guy who is a sweet mate,
Hunro [SP], from South Africa that was with me for couple… You know, he was fasting. He was there for a couple of days. He’s gone back, but fixed his eczema completely. So, the idea that there’s something there
that the body when it gets in this really restrictive mode, starts to repair things. That’s not so farfetched. [Rhonda]: No, it’s been shown. [Ray]: But it’s so long ago. And how do you sell it? Like, people say, “Well how do you sell sitting
in a room drinking water?” You know, it sounds crazy. But I think it’s something we really need
to be ranked at science. I think we need to look at the intersection
of this. So, starting last year, I did a series of
experiments where I was changing my diet over a 6-week period. And what I was able to demonstrate is that
I was actually able to lose body fat at about the same rate as when I was water fasting,
which to me is pretty neat. You know, by just doing some simple changes,
that’s the kind of thing I used when Penn Jillette lost his weight. But the point is that in seeing that I could
function on so little, it seems like the basis where we start, where your stuff then picks
up, which is, “Okay, we get down to this, basically, we’re not overly nourished now,
what things do we need to deal with? What other kinds of supplements? What kind of things we need so that we don’t
get the the dietary restriction without malnutrition? How do we add that back? And now, having experienced it, it seems like
something that I think will be a part of my lifestyle for the rest of my life. [Rhonda]: So, you getting to this dietary
restriction without malnutrition, we have a lot to talk about with dietary restriction
and its effects on the human physiology. But did you supplement with anything? Was this like, so this 21-day fast were there
any vitamin, mineral supplements, like, along with that? [Ray]: No, and that’s the surprising thing. I’ll show you my nutrient panel. Even lasting with 14 days, my vitamin D went
up, it didn’t go down because I was in sunny California, lying in the sun, that was beautiful. I wasn’t deficient in anything. All my blood panels turned out normal. On day 7, I did around the clock amino acid
panel, where I did all the amino acids in there, several metabolites that are in there. And of course, they tracked with the circadian
day, just like you’ve talked about. They’re not something that are fixed. This idea that we’re eating protein and it’s
pumping in our bloods. It’s always there. But they do cycle with the day. Of course, things like alanine, which is mainly
used for the gluconeogenesis, it went through the roof, lipids go through the roof. So, there’s some changes, certainly some physiological
changes, but I wasn’t deficient in anything. The idea that we have to have nutrition every
day and this balanced meal, that’s one of the things that I really want to challenge
because I do think we need a comprehensive nutrient adequacy across the spectrum. It is probably measured in days or weeks,
not every single day. [Rhonda]: Yeah. So, in terms of, like, the micronutrients
and certain micronutrients that are needed you’re talking about B vitamins, vitamin K,
selenium, zinc, magnesium, the question still remains, like, what is an adequate level because
a lot of the RDAs that are set are set on, based off of animal studies that have been
that have shown that deficiency can cause death. And so, like, the couple standard deviations
above that are what are considered what you need. But the question is, and this something that
my mentor Bruce Ames has proposed and put out there and I know that you’re familiar
with, it’s something that he calls Triage Theory. And that is, well, there’s all these enzymes
and proteins that require some of these micronutrients as cofactors that are not essential for short-term
survival. So, if you’re deficient in it, it doesn’t
matter right now because it’s not needed right now. It’s needed for a long-term survival, it’s
needed to repair damage that’s constantly happening. It’s needed to prevent things like cancer,
Alzheimer’s disease. So, the question of deficiency in and of itself,
I think, needs to be challenged. I think we don’t really know how much of these
certain micronutrients we need to make sure DNA repair enzymes are still working, to make
sure our tumor-suppressor genes are working, to make sure that all our antioxidants are… You know all these pathways that need these
micronutrients are getting their cofactors that they need to work optimally or to at
least be working as we’re aging. So, I think that’s… If we look at something like a blood panel,
I mean, “Well, we’re not deficient.” Based on what? Based on the short-term functions because
we don’t know, right? [Ray]: Well, yeah, but at the same time, we
also don’t the consequences of over nutrition. You know, we get a massive excess of a biologically
active compound in levels that we would never would have seen in nature. And we’ve seen it with vitamin E, we’ve seen
it in vitamin D, we’ve seen it in some of the other ones. So, the question is here first if we stop
thinking about our diet as a daily thing and start thinking it as a lifetime thing, then
things change because there may be things that are very much something you do. I mean, you guys are in prime reproduction
time. So, to get fecundity to go up and be more
fecund, we want to increase essential amino acids. We know that things like methionine, whatever,
increase fecundity. At the same time, where I am, which I’m done
with that process at 51 that I want to make sure that have longevity. And they’re also negatively associated with
longevity. So what I feel like where we are right now,
the science and things we can be doing in the next decade, is taking this body of knowledge
and yes, we can start peeling the onion more and more and more mechanistically. And now, we’ve spread that to all the blogs
and they’re peeling the onion. But every now and then, they cut off and forget
half of it. They just sort of put these technical words
out there. But how do we bring it back that look at something
more comprehensive? How do we look at healthspan, you know? Before we lengthen life, we need to lengthen
healthspan. And I’m saying that if we look at…if I’m
not deficient… The average person thinks if they go without
a meal, their metabolism is going to to crush, for example, right? And this will be… We’ll finish with the micronutrients but we’ll
go to the macro level. But if they think that by skipping a meal
something’s going to happen or by somehow not including some food group or something
in every single meal that somehow, they’re going to be deficient. You know, the ubiquitous the evil words I’ve
told you before: protein, carb, and fat. I hate them. If you get on my blog, you’ll see why. But no one’s going to be deficient in protein,
really. And if they’re going to be deficient, it’s
going to be one of nine essential amino acids. We know what they are. We’ve studied them quite a bit. And the fact of the matter is that for the
average person out there, we also know that those nine happen to be connected to longevity
too. And no one is looking at that part. So, my point is looking at this as a spectrum. So, originally, we looked at diet because
of the economics of food and the scarcity of food. If you don’t have enough, it’s great that
every single thing meets a certain minimum, right? So, when these rules of eating were developed,
and we can look at some of those later because I have all of those USDA guidelines from the
turn of the century, which are just fascinating. Because they actually said why they did it
and today, they have different reasons but they say the same thing. And that’s kind of spooky to think about. We’ve made up new reasons for the same explanations. But anyway, if you look at what they said,
if you think about the average person is spending 60% of their income on food. And when you’re at a situation where you have
a limited, if you look at this as a budget thing, more people may relate to it. If you’re in a budget, and you’re barely making
off each month, every dollar counts. But the value of $100 to me and a billionaire,
it’s still a $100. So, the point is that every dollar counts
the closer you get to what you’re meeting your needs are. So, this idea of balanced meals, and balanced
diets, and balanced nutrition, always being deficient came at a time when people really
were deficient. Deficient, deficient, deficient…enough to
see the diseases that we’ve identified. Now, what you’re saying… [Rhonda]: Their gums were falling out because
they’re getting scurvy. [Ray]: Right. Yeah, and where you’re at and I am too is… Okay, now, in addition to that, not necessarily
what we are deficient in, if I change the language and say, “What more can we get at
the micronutrient types, the…” [Rhonda]: What do you need? [Ray]: …all the phytochemicals to maximize
and optimize our longevity. You know, there isn’t any perfect diet. We’re not designed to eat anything. We can eat everything and that’s why we’re
spread everywhere. But I think, somehow, this construct of food,
and the construct of the balanced meal, and the construct that it happens in a single
setting versus spread out over days or weeks, where I think the body is… It’s much more rational to me to think that
the body deals with it several days and weeks and doesn’t become deficient instantly. I think that’s where the attention needs to
focus. And there’s really no money right now to be
made in that. I can’t sell somebody something. I can’t sell them more supplements. I can’t sell them more trainings. I can’t sell them more exercise. And so, it’s kind of a trap. But I think there’s people like you and I,
and some of the collaborators I’m working with and yours too, that’s just intellectually
curious about it. But we need to bring it back to whole food,
we got to bring it back to foods that… What can we get out of what we have? And then, what’s leftover to supplement. [Rhonda]: Right. So, you were eluding a little bit to some
of the studies on dietary restriction and I think it’s important a lot… In science, dietary restriction doesn’t refer
to the extreme type of restriction that you just underwent. [Ray]: Yeah. Can I make…real quick… Let me explain how I tell people about this
because before I started doing this research, the way I saw it was overnutrition, too much,
normal diet, deficient, undernutrition. That’s what was in my head. As I began to read, a lot of that dietary
restriction without malnutrition work and I’m now always at the end, what I realize
is probably, what’s more a thing is there’s overnutrition, which is actually a small bar
because in nature, it’s really hard to do that. [Rhonda]: But how do you separate overnutrition
from giving people getting too much of your amino acids, too much of fatty acids, too
much glucose without getting the micronutrients. [Ray]: Right, but let me talk the big… At the big block level first, overnutrition
is a sort of a small little thing because in nature you don’t really have it. Normal nutrition is what we would normally,
in a normal healthy person would eat there. But then there’s this all diet restricted
without malnourishment, which I would say is a big block because that’s human survival. We have to be able to survive periods of this
up and down with nutrition. And that’s a big block. And interestingly, the things you and I are
most interested in, the micronutrients, which are all coming from these leafy green plants,
are actually abundant. You don’t get much calories from them, but
you can find them all the time. And then when they’re stressed, xenohormesis,
they may be actually given us even more. So, you got that… And there’s undernutrition. When I added this extra block and said, “You
know, I call it the survival block.” That block is a place where we likely lived
and we likely survived, not optimally we don’t have parasites. We don’t have infectious disease. We don’t have the things they were battling. So, we can, maybe, leverage that to live longer. So, now, back to what you were saying. I think we that we don’t know. I don’t know that we know where that upper
limit is. But I know that, from a calorie perspective,
and I hate to use that word too, because it’s misused a lot… And then there’s people that even question
and we can talk about that in a minute. But we certainly are overnourished from just
the calorie-density perspective. You know, we are. And this is disease of affluence. We have so much disease of affluence. You can go to countries that don’t have access
and they don’t get the same disease. They get the wealth in China, India, and then,
they come with it. [Rhonda]: What’s so interesting is that, and
ironic, is that at the same time that we’re overnourished, we are, according to a lot
these NHANES studies coming out, we are getting inadequate levels of many of these micronutrients. Think, if you’re over nourishing yourself
that you would then would have adequate levels of these micronutrients. But the thing is, people are eating the wrong
food. They’re eating the wrong foods and so they’re
not getting all their folates, vitamin K, selenium. They’re not getting all these important micronutrients
and yet, they’re getting, a lot of fatty acids, amino acids. They’re getting a lot of the macronutrients
that people like to call them. [Ray]: Macro, that’s right. yeah. [Rhonda]: And it is a big problem, you know… [Ray]: Yeah. And what we try to do to address it and we’ve
got a series of papers coming out, but the metabolic winter hypothesis is already there. And the food triangle, one of the reason we
do it… Because first of all, ideology aside, this
sort of eat meat, don’t eat meat debate is boring to me and I never even go there. You know, we’ve talked about it that night,
it’s just gets to be old. So, this isn’t a…it’s not that. But it turns out, animals are biologically
very similar from a…that’s why we use them for models. They’ve everything. And plants, are very fundamentally simple. And it just so happens, mostly, the energy
that you get from animals is mostly fat. And the energy you get from plants is mostly
dietary carbohydrate, and I won’t say carbohydrate again, except for nuts, and seeds, and avocados,
and things like that, that have significant amount fats. But when we look at it and draw this food
triangle, what we put at the top were the leafy greens, the cruciferous vegetables,
stems like celery and asparagus, mushrooms, and bulbs, which is what? The vast majority of what you eat every day
should come from the top of this thing. If you eat the majority of this food, the
volume of food, if you just eat the volume of food… Now, you have a choice. If you eat on the left side, which will be
kind of a Paleo Diet, you can maintain your weight but you won’t get as much fiber, you
won’t get the extra phytonutrients, the extra things that are over here because you end
up calorie displacing, energy displacing. If you start adding all these stuff, because
as soon as you start adding this part over there, you start going over your energy limit
and now you still haven’t gotten to where you and I want to get, which is enough of
the micronutrients. On the other hand, when you add on the plant
side, what’s interesting is, you get great things in fruits and berries, nuts and seeds,
I mean, every single issue of “American Journal of Clinical Nutrition” just about has a study
on nuts and seeds, and the flavonoids, the carotenoids, all the those that are in nuts
and seeds. You get… [Rhonda]: Legumes. [Ray]: …legumes and big one I mean, that’s
a huge life of…you look at the, what is it, the book? “The Blue Zones” [Rhonda]: “The Blue Zones” [Ray]: You know, legumes are big part of that. [Rhonda]: So, this part of it, is it the right
side of your… [Ray]: The right side of… [Rhonda]: …of your triangle? So, it’s a lot of plants, nuts and legumes,
right? [Ray]: Yeah. Basically, the bottom of that side is cereals,
pulses, which are legumes, starchy vegetables, fruits, and then to a small thing, which is
nuts and seeds, which we separate just to distinguish the fat content. [Rhonda]: From an aging perspective, so a
lot of people have different goals. My goal is to have a healthy and extend my
healthspan. You mentioned healthspan. And what that really means is to…you’re
not necessarily going to live to be 200, but you when you are 90 years old, you’re going
to be physically active, fit. You’re going to be biologically 20, 30 years
younger, 40, 50 years younger. You have a brain… [Ray]: Most people don’t guess me at 51. [Rhonda]: Right. So, the thing is that there’s a chronological
age and there’s a biological age. And you want to be biologically younger, like,
who cares what your chronological age is? And the thing, to bring it back to the legumes
and plants and the nuts and seeds is that if you… Recent study has been published by this Japanese
group where they looked at a variety of different biomarkers that are age-related. So, these scientists looked at telomere length
markers of senescence. They looked at hematopoiesis. They looked at glycated hemoglobin, blood
glucose levels, insulin sensitivity. They looked at inflammatory cytokines biomarkers
of inflammation, biomarkers of all the inflammatory pathways. And they looked at it in three different populations
of people: the elderly, which are about 85 to 90 years old; centenarians, which were
100 years old; and then, semi-supercentenarians, which are like 105; and then supercentenarians,
which are 110 up to 115. And to me, if you look at the average lifespan
in the U.S., it’s 79. So, it’s close to 80. Well, if we know right now that humans are
physically capable of living to be 115 years old, that’s almost, you can round up, 40 years
longer lifespan. That’s like a 50% increase in lifespan. That is huge that we’re doing… Right now, no science fiction, no nanobots
involved, no CRSPR, nothing. It’s already designed in our biology. That’s possible, right? [Ray]: And in some of those populations, some
of them just are sort of outliers, where they just live long. Some of them are fully functional. [Rhonda]: Exactly, healthspan, yes. [Ray]: Yes, they’re fully functional. [Rhonda]: Fully functional with cognitive…I
mean, they’re… So, my point is that the only biomarker that
was identified to drive the aging process in all three categories, the elderly, the
centenarians, semi…or all four, was inflammation. Inflammation was inversely related to age. It’s the longevity. And when you think about the human body and
biology and physiology, the number one driver of inflammation in humans, in our bodies,
is the gut. The gut is where we have the highest concentration
of immune cells, it’s where we have the highest concentration of bacteria. And when those two combine, you get war firing
away of cytokines. And that’s the major source of all inflammation
in our body right there. And what has been shown in countless studies,
particularly over the last five years is that the gut likes fiber. These it… [Ray]: And not only that, but the gram-negative
bacteria, the fat-loving ones, those are the ones that are usually the most inflammatory. And I did a post on this a couple of years
ago. And I think there are two really big things
that are going to end up coming out of it. First of all, fecal transplants, in our lifetime,
will actually, I think, be a part of aging. I think we would end up that just basically,
that microbiome, keeping it ripe because of antibiotics, because of the things that we
do in life that destruct. You know, I usually tell people, “You know,
you send 12 Amish men to a rock concert, they can have a great message, get up on stage. But the environment is not conducive.” And in that microbiome, they are what we eat. Their waste products go in our absorption
organ. And this is critical. And it’s not just because we’ve seen all the
transplant studies we’ve done in mice. It’s not just eating the food, but it’s also
having the right distribution down there. And all it takes is a little bit of wrong
things and then you get an explosion of something. And so, again, what’s socially extreme may
not be biologically extreme. The kinds of solutions we need to have for
that and the kind of fiber in the food. And what we need to do, on the right side
of the food triangle, I guess, I should just say right, for the audience. On the right side of the food triangle, all
of those food we’re going higher and higher in fiber. [Rhonda]: Right and it’s interesting that
these different types of fiber, like with different types of beans and nuts, they’re
fueling different types of bacteria. And they make these byproducts that are literally
regulating our immune system, they’re regulating hematopoiesis, they’re increasing the amount
of t-regulatory cells to regulate autoimmunity. They’re decreasing all these immune cells
that are firing away… So, they’re regulatory the inflammatory process. And gut, that’s point on… [Ray]: And all these, well, oligosaccharides… [Rhonda]: All those, exactly… [Ray]: …that you feed them. And that’s just crazy, all the things that
are going on there and yet, if you think about what we’re doing is we’re, first of all, we’re
deluging that from the time we wake up in the morning until the time we go to bed, we’re
just always in the chronically fed state. We weren’t in the chronologically fed state. And in our next paper, one of the next papers
that we’re having, it will talk about the implications of the chronically fed state. So these brings up, what you talked early
about, is intermittent fasting. And when I was looking at a lot of these,
again, my first twist of this was to look at the metabolic thing. So, let’s get metabolism out of the way because
this other stuff is a lot more interesting to me. But this, in terms of metabolism, everybody
wants to think, “I need to increase my metabolism.” “I’m going to eat this meal, it’s gonna…” “I’m eating this protein shake, my metabolism
is going to rise.” Well, it turns out, I’ve not measured a single
broken metabolism in three years of my life. In a 100 people, no one has a broken metabolism. Your metabolism scales with your mass, pretty
much, you know? Inside, whatever size you are, is your thin
lean self. You have that thin lean self to steal a cloth
on what you lost and carry it out all day, and that is what happens. But, what’s really interesting, now on the
extreme side. So, I could say all these in terms of food,
but when I was dieting, even doing extreme dieting, by everybody else’s…just a very
low-calorie diet. [Rhonda]: Your 21-day is extreme. [Ray]: What I’m saying is, before even that,
just in the things that I do, where people lose weight rapidly, with most people that
I work with lose weight, 0.6 to 0.8 pounds of fat a day. And that’s without exercise. The exercise… [Rhonda]: is that with cold? [Ray]: No. [Rhonda]: No cold? [Ray]: No. Cold is part of it, but it’s not part of it
in the way you’re thinking of it. So, I use it as adjunct therapy, but it’s
not to increase the metabolism. [Rhonda]: We’ll talk about cold later. [Ray]: Yeah. So, basically, though, what’s interesting
is that in all the different regimes, my metabolism always tracks with the Francis Benedict equation. And when we go back later, I’ll show you. I’ve got the 1918 study. I’ll show you. I’ve all their data. The point is those guys did this research
and what they did is right and what we’ve done today is we have popularized these words. And I literally have debates with people about
metabolism… [Rhonda]: Can you define what you mean by
metabolism? [Ray]: Yeah. So, what I’m talking about is the net sum
of respiration of all your cells. So, the way we measure metabolism is we measure
the carbon dioxide, exhale, breath by breath, and the oxygen that goes in and then oxygen
that comes out. So, we know the delta oxygen. We know the carbon dioxide. And so, the ratio of carbon dioxide to oxygen
is called the respiratory quotient or RQ. It tells us like a thumbprint what fuel we’re
burning. So, if you look at this general stoichiometry,
like the combustion of ethanol. Ethanol plus oxygen equals CO2 plus water. And you do the balance equation like you did,
you’ll see that you get a three on one side, two on the other or two on the one side, three
on the other…no, two and then three, and you get the respiratory quotient of 0.67. So that’s a number. So, if I’m mainly metabolizing alcohol, my
respiratory quotient will push down. Carbohydrates of all kinds, it doesn’t matter
what kind they are, all of the glucose, anything that’s dropping in there, those have a respiratory
quotient about 1. And then fats or lipids, are around between
0.69 and 0.7. So, what’s really interesting is that…and
amino acids, they average 0.84, if I average all of them. So, proteins are kind of mixture. One protein might be slightly lower, slightly
high, but they average 0.84, which is great because the only way we measure protein is
not through the carbohydrate because by that time, the deaminations happen. You’ve lost all that energy through urea and
it looks like sugar coming out otherwise, right? But what we can do with protein is we collect
the urine, which is why I’m carrying an orange jug around all day. Too much information but it’s science, right? So, we get the nitrogen from the urine and
then we can back out. But by knowing the carbon dioxide produced
and the oxygen, we can see the ratio of glycogen to fat burn, real time. [Rhonda]: And you’re saying that you have
not seen someone’s metabolism that’s been broken? [Ray]: Meaning they’re at their… Their metabolic rate, which will be like speed
of the car, is what all of the industry is focused on. Everybody wants to increase their metabolic
rate. What I’m saying is how fast you’re going only
matters if you’re headed in the right direction. You need a compass too. And RQ is kind of a compass. It is the indicator. Am I burning mainly carbohydrate or am I burning
mainly fat? You can run your ass off for hours, and if
you’re only burning carbohydrate, you just get on the glycogen treadmill. And so then, what people do to counter that
is they say, “Oh, I’m going to remove all the carbohydrate and shift my body into ketosis
so I’m burning fat all the time. So that when they’re running, they are burning
fat. But, again, it’s not necessary because it
turns out, when we become more restrictive, your body is smart. And when we become more restricted, you naturally
start shifting to more and more and more fat because your body knows to reserve glucose…conserve
it. It wants to. So, where I’m going with metabolism is that
all the discussions we have about metabolism, about boosting metabolism, about all these
things, even cold stress, a lot of them fall into that simple thing I said earlier, which
is we use to eat to support our activity because food was rare. And today, we’re active to support our eating. And the more simple thing is you can’t out
exercise your mouth. It’s impossible. It’s thermodynamically impossible. You can swallow way more than you can move. It’s just not… So, while I was talking about metabolism,
what I’m saying about not being broken is, you don’t have a slow metabolism. That’s not your problem. It’s not that you have a slow metabolism. Now, you got to get hormones to speed up your
metabolism that nobody, by the way, ever measure. Isn’t it amazing? All these people talk about metabolism and
they don’t measure in. So that’s what I started to say earlier was,
I have these debates. And I say, “You know, how metabolism do you
measure? Do you know anybody who’s measured a metabolism? Have you ever touched anybody that measured…?” And the answer is most people never made it. And I hadn’t. I was talking about metabolism. I was guilty of all the same stuff. I’m, you know… But once I started measuring it every day,
when we measure yours later, you’re going to find, it’s way more dynamic than you think
it is. It’s way… And then, I mean, because you are very precise
about the things you want to know. This one is really going to mess with you
because it’s not what we think. So, this boosting the metabolism, we’re going
to boost metabolism. Now, cold stress, we’ll come back to it when
we talk about cold stress because there’s some really specific things on cold stress
and really some specific numbers that I can give you or I can show some things that I’ve
done with cold stress, which is kind of interesting because it turns out mild cold stress, naturally
tends to lower RQ, meaning shifting towards fat. So, and we’ll talk about that when we get
to that. But to sum up metabolism, we’re not broken. And that’s one of the things I’m going to
try to talk about in our book in more common language. I say, “Well, we’re not broken. Let’s not start with that let’s start with
the food we’re eating and the social environment of how why we eat.” And then, superimpose on top of that my benign
conspiracy or I could say our benign conspiracy, which is I really wanted people to shift more
to healthspanning. I want to shift more towards to a kind of
a diet that will promote healthspan because it’s really embarrassing that the community
we run with, and we know all the people we’re talking about, the community we run with that
are talking longevity and talking about all of those stuff, and they aren’t eating well. And if we can’t, like, we know this stuff
works. Like, you said earlier, we know it works now. We don’t even… We just have to do it. [Rhonda]: Well, who doesn’t want to live a
healthier life and be younger when they’re older? I mean, who doesn’t want to not be crippled
and degenerated and…? [Ray]: Arthritis. [Rhonda]: Yeah. Who wants any of that… [Ray]: Heart disease… [Rhonda]: ….pain? [Ray]: Diabetes… [Rhonda]: …suffering. I mean, all that, yeah. It’s like, I think that eating to increase
your healthspan, I think, it is my goal and I think that it is a lot of people’s goals
even if they don’t realize it. Even if they don’t realize it. [Ray]: And so, the one twist, what I would
say, the pause that I think we should do now, to think about just a little bit, is I think
my vision of doing what we’re talking about before was about slugging how much stuff that
I could get in my body that was helpful. And now, I’m not so sure that’s right. Now, I’m not so sure that that…in doing
so, I might unintentionally over nourishing things that I really don’t need to. So, let me talk. In my specific diet. Since for me animal products are rare and
appropriate. So, what do I mean by area and appropriate
is its people and places. It’s not how often I eat something. So, I’m not the person that says, “You know,
I’m going to have sushi every two weeks. Or I’m going to have…whatever.” It’s people and places. So, for example, with sushi. It’s something that I absolutely love before. Now, if I eat it too often now, my diabetes
comes back, you know. I hate to ruin everybody’s party. It may not happen for everybody but I know
because I have a glucose monitor. [Rhonda]: I’ve seen… [Ray]: I know exactly what it is. [Rhonda]: …your data. [Ray]: Yeah it’s like right here. I know exactly what my blood glucose is at
any minute. And so, I know what it is and I know that
it comes back. And so but my son really loves to eat sushi. So, for me, if he wants to go and we’ll go
do that because I don’t tell my kids how to eat, they mostly eat like me, but they eat
whatever they want. And we’ll go. I’ll have a big bowl of rice or I’ll have
something before that fills me up. And then, maybe, I’ll have a couple of pieces. We’re having fun when we’re doing that stuff. I don’t go pig out on sushi. I just don’t do that anymore. Or we make our own. So, I make all the sushi that I do with mushrooms
and lots of other things, which they love just as much, especially because you can eat
as much as you want. You know, it feels great. You know, so it’s inexpensive. I shop at the Asian store. So, anyway, back to the food triangle. You know, I eat on the right side of the food
triangle and I get nuts, seeds and avocados often. And I eat lots of fruits so I have fruits
around all the time. I’m not glucophobic like all these people
think, “It’s sugar.” Well I don’t eat refined sugars. But I eat that. If I want a sweet in something, I use a date. But what’s really interesting is that as my
diet has change, my palate and my taste acuity has changed immensely. And recently Penn Jillette’s been posting
on Facebook and he’s says… First, he was saying I ruined him. And somebody corrected him and said I fixed
him. But now, even in his eight months’ time, he’s
eating these things, like making this big blow out for show and he’s not enjoying it
as much as it…”I just don’t enjoy those things anymore as much as I did.” So, I get those things. But what I’m not doing is I’m not doing the
all-day eating thing. So, I don’t start with the smoothie and do
this, and do this, and do this. I tend to compress my eating window so I’m
kinda naturally doing alternate-day fasting, or every other day eating, or intermittent
fasting because I’m just decreasing my meal frequency. And I eat a lot of food. You would not believe how much I’ll eat. And that’s why a lot of people say, “Oh, yeah,
I went vegan and everything start happening.” Well, most people just don’t eat enough food. And clearly, we can live off this, if our
primate cousins are fine. So, there’s not a debate there. And if you’re eating junk food, the worst
place to try eat healthy food is a vegan restaurant because they basically just shake sugar, salt
and fats and put it on plants. Like the Western diet takes sugar, salt, fat
and throw it on meat and stuff. You know meat is the delivery system for sauce
when it really comes down to it. Anyway, when I’m eating on that right side,
what I try to do is decrease the frequency. And that’s where I think it’s kind of neat
because I do think blending, for example, not juicing but blending… I know you’re an advocate too. [Rhonda]: Yeah, you need the fiber. [Ray]: I think, well, I get tons of fiber
in my diet because I eat an enormous, enormous amount. But I think blending certainly ruptures the
cells, certainly get more access. There’s some study on that. I think we do more on that. Where I’m excited is like this summer I did
all hydroponics. I grew all my greens. And I’ll show you some of the pictures, but
two weeks from seeds to harvest. I use the vertical earth garden. It’s an amazing thing. And I’m growing. But what I think, what if we start stressing
these plants and go into that next level? You just go and beyond even that. [Rhonda]: So, we need the, probably, explain
a little bit about that. But first, I want to ask you with your intermittent
fasting, do you usually eat in mornings, like, evenings? When do you actually take in most of your
food? [Ray]: I tend to…I’m not a morning person. I’ve never eaten in the morning. I get up early. My best thinking time is between, they say,
4:00 a.m. to 9:00 a.m. That’s where I can really do. I taught myself a year and a half ago to sleep. I never could get back to sleep my whole life,
so there’s not very many times that I slept past 7:00 in my entire life. I’m like, even if I go to bed, like, my circadian
it’s hard to get up. But I taught myself how to go back to sleep. So, I’ve been trying to sleep so I can go
get in [inaudible 00:39:20]. I’m averaging right now, I’m averaging eight,
nine hours of sleep, so… [Rhonda]: Are you tracking your sleep right
now? [Ray]: Yeah. I’m tracking my sleep, so… [Rhonda]: Is this like your own thing or is
this like an app? [Ray]: This is the Withings app. This is the Withings Aura. So, I have a whole suite of Withings things. They have the Aura that measures your sleep,
the Scale which… [Rhonda]: Can you spell that? [Ray]: Withings, W-I-T-H-I-N-G-S, and they
have the Sleep. And this Activite, or whatever, the Pop. This guy measures sleep too. So, I have that. You know, they have the camera that measures
the VOC, your scale measures CO2. So, it’s sort of interesting because it matched
your environment, what kind of environment you’re in. But I’m now sleeping way better. And we talked a little bit on you Facebook
page about melatonin. We can get it at in second too, but, so, I
tend to eat in the evening or in the afternoon. And because I’m working out of my house, it’s
just when. So, one of the things that I try to teach
the people I work with is, don’t name a meal. Technically, the first meal is “breakfast.” You’re going to “break-fast” tomorrow. And it’s going to taste really good. But, and then I don’t…naming meals is convenient
for restaurants so they know what they serve you, right? But there’s not time of day eating and there’s
not time of day foods. It doesn’t matter what you eat, where you
are, whatever. This idea that you’re fueling your body for
the day, it’s just not true. [Rhonda]: Well, the one aspect that I think
I think that is important and that has to do with the circadian rhythms. So, in the morning, you’re the most insulin
sensitive. In the morning so the way our metabolic enzymes,
they’re going on a rhythm. So, there is that component. And the reason I’m sort of interested in it
is because I also will practice intermittent fasting and I’d like to talk about the aging
aspects of that. But it used to be that I was fasting the day
and just eat at night. And that’s mostly because my husband, Dan,
can’t sleep if he doesn’t eat something before bed, which is like he can’t sleep when he’s
hungry. And there’s some truth to that, right? [Ray]: There’s several people that are like
that. There’s some people that are like that one. [Rhonda]: Yeah. Well, recently, we were traveling in Europe
for a while and we were doing Airbnb’s and so, like, we wouldn’t have any food, like,
so if we were eating, we would eat mid to late afternoon, like, 3:00 or 4:00, the latest. And that was it. So, like, then, I was done and didn’t eat
anything until the next day. And what I found is that I really felt really
good doing that, which is the opposite. So, I started not eating like right before
bed, whereas that’s what was, been doing originally. [Ray]: So, to back that up, talk about glucose.
if you’re eating starches in the evening, instead getting those sharp peaks that you
all saw today, the sharp peak like this, you’ll get tailing. So, this is true. I mean, there’s no doubt that you get tailing. Glucose doesn’t clear as fast the later in
the evening. So, I’m not talking about night. I’m talking about night I may eat at 2:00
or 3:00 in the afternoon, and then maybe I’ll eat at 5:00, or 6:00, or 7:00, you know. I’m not a late… [Rhonda]: Not like at 10:00 p.m. [Ray]: I don’t eat it like… No, I don’t do that. [Rhonda]: That’s what’s so dangerous about
lot of people. And there were times when I’m working late
and I don’t get home until 8:00 p.m. or 8:30 and then it’s like, then I have to cook and
then dinner is not ready until 9:30. And it’s like, that’s too late. [Ray]: And I have a weapon because I have
this third option. Don’t eat. [Rhonda]: Don’t eat. [Ray]: And once I freed myself, I’ve been
on a business trip for two days and came all the way home and the only thing I have from
the time I left to the time I came home was water. [Rhonda]: Yeah, I actually did… [Ray]: And that seems radical, but having
that option is a tool in our tool kit. [Rhonda]: it is radical, but I agree with
you. It doesn’t have to be two days. It can just that night, for some people. And I do think that I know several people
that are late-night eaters. They’ll not eat in the morning because they’re
so busy and they’d work, work, work. But it’s not until later in the evening, and
then they end up eating around 10:00 at night. And you’re the most insulin resistant at 10:00
at night. And it’s like, they have problems with metabolism
problems and weight loss and all these things. And I think that it’s just…it’s not healthy
just based on what we know from circadian rhythm, just based on that alone, we know
that that’s like the time that you’re not supposed to eat. You’re not supposed to get all these, like,
glucose and fat and everything… [Ray]: I can’t wait until you see our paper
because we’ve got some other explanations that will go right along with this. It will actually, it will superimpose well
with this. And I completely agree. So, it’s… [Rhonda]: I’d love if you would like to talk
a little bit about caloric restriction or dietary restriction, which is what we know
call it, and intermittent fasting. And, like I’ve seen some studies comparing
the two in terms of longevity and how there’s similar effects in almost every respect in
terms of the metabolic effects, glucose metabolism, in terms of brain atrophy, brain aging, multi-organ
aging all being delayed. The one difference that was found in this
paper, and I forgot which group it was that did this, and it’s pretty recent was that
when they challenge the brain with some sort of a neurotoxin that can cause neuronal cell
death, the intermittent fasting was protected, but the caloric restrictive or dietary restrictive
was not. And they hypothesized with the ketone body,
whatever… [Ray]: And I haven’t got into that part. So, this is…what I’m doing right now is
my lead-in. My point was, first, when we start with the
idea of fasting and expand it beyond what you do to take a blood test. In other words, this idea that we’re “fasting”
every night, this is not where I’m going. So, when we start the fact that here I am
at 23 days and I’m fully functional, I don’t feel bad. You guys have been with me, running upstairs
doing this stuff. [Rhonda]: We’re having this conversation. [Ray]: Yeah, it’s fine. I mean, it is…you do get a little foggy
at some point. So, you’re not as on top of things. Like I told you earlier, words are more difficult
just it’s kind of interesting to certain things. But if we start from this basis that during
this time we have these amazing healing processes that happen, which I was telling about blood
pressure, 30-point drops in blood pressure in a matter of weeks people with eczema and
all those things that are… So, we have these amazing repair processes
that are happening in the fasting state. And we fast forward… [Rhonda]: Can we talk about why that is? I mean, that’s been shown mechanistically
in animal models and in monkeys. Mice, monkeys have been shown that when you
fast, it is a mild stress on the body. You are deluded to the… [Ray]: Hormesis… [Rhonda]: …hormesis and that causes massive
changes in gene expression. And many genes are increased that are involved
in dealing with damage, repairing damage, anti-inflammatory. All that stuffs being turned on. Go, go, go, go. [Ray]: And the body starts sequestering the
things that it needs. You know, the popular myth is all your body’s
fasting is going to hold on to fat. No, it’s not. That’s your storage organ. It’s going to use the fat. But the point is, is the stuff we’re interested
in your body starts mobilizing. It starts cleaning house. You know, metabolically cleaning house. Going in saying, “Here’s a dysfunction cell,
I need these resources, need this, need this…” Just like what you do when you’re trying to
make things in… You rob around… [Rhonda]: Which is really, really, really
good because those dysfunctional cells, as you call them, they’re often senescent, which
means they’re not dead, they’re not alive, they’re sitting around and what are they doing? They’re secreting inflammatory… [Ray]: …your hormones. [Rhonda]: Yeah, they’re damaging cells in
your body. So, if you can do something to get rid of
that crap, you better do it. And fasting, intermittent fasting, has been
shown to do it. [Ray]: Right. So, if we would get rid of the fasting term,
meaning the overnight thing. So, we lose that. We go to this extreme and say, “You know,
look, the longest medically-supervised water fast was 382 days.” And that 382 days, yeah, 382…276 pounds,
382 days, I’ll send you the paper. Actually, I might have even posted the…on
your thing. But it’s 382 days, medically, in the middle
of… [Rhonda]: Supplement or anything? [Ray]: No. [Rhonda]: Just water? [Ray]: Yes. They did the multivitamin. And then, in the middle of 49 days, they had
to do some electrolytes. But other than that, he was fine. And he weighed 185 when he’s done. [Rhonda]: What did he start with? What was starting at? [Ray]: Well, he lost 276 pounds. [Rhonda]: Okay. So, he had a lot of fat to burn. [Ray]: Yeah, absolutely. He had the energy. [Rhonda]: Right. That’s important, right? [Ray]: No, he’s not… [Rhonda]: If I were to do 380, I think, I’d
probably be dead. [Ray]: I don’t know. There’s probably some breatharians down the
street that would disagree with us, right? No, so the point is, is that… So, that is…but when you say it’s extreme,
what’s interesting is, there’s no reason I couldn’t, other than I don’t want to get much
thinner other than that, there’s no reason why I couldn’t go on and on and on at this
point. The idea that somehow fasting is miserable
was because people are responding to regularly dosing their body with meals. And in the anticipatory habitual stuff that’s
going on, and what do they get? There’s symptoms of hunger: headache, lethargy,
lack of focus, irritability. What happens when you give up cigarettes? Lack of focus, irritability, headache, shaky… Heroin, alcohol, and I’m not saying that food
is addictive in that way. I’m saying the body only knows withdrawal
when you’re regularly dosing it all the time with stuff. So, all of what you feel, what you feel now
is hunger really isn’t hunger. Like, right now, I’m hungry and the only real
symptom of hungry when I say that is that my mouth will water and right now, food will
taste so freaking good, you wouldn’t believe it. Like, I go to cooking classes. They have cooking classes. He would say, “You go to those cooking classes
while you’re fasting?” Yes, because a lot of taste is smell. And surprisingly, my friend, Richard Ross,
he was one of my clients. He’s an amazing…He’s a cephalopod…a scientist
at the museum in San Francisco. What’s amazing is you can just smell food
and believe me, it’s almost as if you ate it. It’s crazy. I can’t it’s like I can’t… [Rhonda]: Smelling food is good. I like, I enjoy smelling… [Ray]: Yeah, but I mean, it’s really intense. It’s like something you’ve not experienced
before. [Rhonda]: Like when you don’t eat and you
just smell it… I’ve not… [Ray]: And it’s almost like you taste it. It’s whatever…but it doesn’t send you into
any crazy feeling because you’re in a perfectly normal state. The body shouldn’t… you know these symptoms
are not a way a starving animal finds food. You got to be clear, you got to be lucid,
you gotta find food. So, okay, getting back to that, the senescent… [Rhonda]: Can I ask you a question? Did any of your friends join you? Like, was this like something that other people
that are also starving also… [Ray]: The people…all the fasting… [Rhonda]: Has anyone ever just like gone crazy
and start eating, like…? [Ray]: No, you don’t have those urges. That’s the point. That’s a myth about what it is because what
people’s idea of hunger and what’s people idea of eating is based on the idea that their
entire life, they’ve never been more than 10 to 15 hours without food. So, first, we had to dispel the myths that
fasting, which is this overnight fasting, which is has it’s point, as you say, hormonally,
has it’s point. But one of the reasons eating late is problem
because then, you eat, you go all the way into night, and then you get up in the morning
and you drink your shake right before you get a workout. Now, what? You got four-hour-a-day fasting. And if all important activities happen during
this down state it’s like taking amphetamines all the time and staying awake just because
you can. The brain needs that time. It doesn’t shut down the… It doesn’t go metabolic. Brain activity doesn’t go away. It just changes. What I’m saying is our body is somewhat…I
feel this body is somewhat the same way. So now if I start from this basis. So, here I am at 23 days, I’m doing okay. Now, I start compressing that window and so,
okay, now where do we get with those health benefits start kicking in, you know? You know, intermittent fasting is some of
it, some of it dietary restrictions. So, you could dietary restrict and be chronically
feed. [Rhonda]: What do you mean by that? [Ray]: You could be eating all day long, very
small amounts, and by a calorie perspective, which is why I don’t like calling it calorie
restriction anymore. I’m going to start… [Rhonda]: Right, dietary restriction. [Ray]: You could be dietary restrictive, but
in the chronically feed state because postprandial, metabolically, we change. [Rhonda]: Yeah. And SIRT1 gets activated every time you’re
making… So, when you’re eating anything when you’re
eating food, you’re going to make NADH, which is which is going to shut off SIRT1, which
is also part of the benefit of fasting. [Ray]: So, feeding frequency, when we look
at feeding less frequency, and that may be a reason that I… We can look at the study with that lens and
say, “Okay. How did they feed them?” If they did the standard three meals a day,
which was just made up, I’ll show you the document of where it was talked about, in
fact, we’ll… [Rhonda]: Wait. What are we talking about? Who? [Ray]: I’m talking about what happened a hundred
years ago, when we started, you know… Hippocrates questioned whether we should eat
once or twice a day. He said “some was the habit, some was the
season, some was the age, some was to country where you live”. In other words, people were eating once or
twice a day. Literally, they just don’t have a lot of food. They didn’t shut down the pyramids three diet,
three times a day to feed those guys, you know? They said, “Chisel, pull the rope, here are
some water.” And then, they give them some bread later,
you know. And they managed to do something that we can’t
do today, right? So all alien theories aside, right? So, basically, what I’m saying is that we
have this template that fits around, first the agricultural cycle, which I grew up on
a farm. So, eat a small little something before you
got out. Stop, early 11:00, have the biggest meal then
while the sun’s out. And then, it’s a long day. You go there and there’s a light meal towards
the evening. And that’s where this thing, three meals a
day. Now, for the workforce, its eat before you
go to work. Have a break, have something to eat then. Go eat lunch. You know, now have a break, go have happy
hour. Go home eat again. And then, you’re…late nighters are obviously
even worse. Go grab a round of ice cream before you go
to bed or whatever. That’s a chronically fed state. What I’m saying is, you can be in a chronically
fed state and still have just a little bit of calories, you know. You might lose body fat, and I’m not saying
you won’t be at a deficit, what I’m saying is this idea that you’re always slugging… Every time we slug, we activate a whole set
of hormones and react to it. And so, we talk about fasting and we talk
about intermittent fasting, the idea that you’re really going long periods. But even in the popular media, because everyone
is terrified to say, “Don’t eat.” You know, you’ll be anorexic or whatever,
you’ll have an eating disorder. But the idea that you can last a day or two,
I mean, really, I mean anybody tells me, it’s like they’re experts. And I say, “You can’t use fat for metabolism,
like, how many days have you been without food?” Like, exactly… [Rhonda]: Well, this is a question I’ve been
trying to answer for myself and that is what’s the minimal time that I need to fast to get
the autophagy benefits? Autophagy is clearing away those damaged cells
we’re talking about. And there’s other benefits. So, there’s lowering IGF-1 there’s SIRT activation. That stuff, SIRT, can happen quickly and I
mean, as soon as NAD… [Ray]: So, just to give you an idea of my
last fast, although it was…I did it over my IGF-1 went down to 69, at the end, I was
at 69. This one, I was really interesting. I started 200. So, gaining the weight and eating…and I
ate healthful things to gain the weight. But I did stuff to get up there, and I was
massively eating two or three days before I really want to have a negative experience
with fasting. I really wanted to really set off the hunger
pangs that I’ve seen people have dealt with that. Most of them don’t eat my diet before they
fast and that the people that don’t eat like me, they’re really sick. I mean, they don’t do so well. So, I wanted to try to do that. So, for about four or five days before, and
I didn’t really gain weight during that period because I was eating…my food is really hard
to gain weight on. But, so I was done with the weight loss, I’d
already gotten up to my weight at the start, and I held it for about a month or so. And then, two or three days before I started
the fast I just started eating three meals a day healthy food but just really eating
a lot of volume of it. And my IGF was surprisingly… [Rhonda]: Do you eat a lot of meat? [Ray]: No, I don’t eat any meat. [Rhonda]: Your IGF went up. [Ray]: Yes, it went up. Yeah. So zero I had none. I mean, I just had, it’s just dull, whatever. And it was up at 200. And then, by the midpoint, it was already
down to 100. So, it dropped 100 points in 7 days or 10
days. And we’ll see what it is. I already did the last one, results will be
back soon, we’ll see what the ending is. Last time, like I said, I ended at 69. So, but anyway, why I’m saying that is because
I haven’t seen a lot of work out there on this, but I think there might be data that
we could tease out of papers that exist. This is something I want to think about as
sort of a next step, which is this meal frequency. You know, how often we’re eating could be
a huge problem. I mean, just frequency. Unfortunately, it’s the social. You and I, as scientists, are able to sort
of ignore the social… If we think we’re wanting to do something,
we get headstrong we’re going to do it. Right? And you just don’t care what people say and
neither do I. But a lot of people out there, they’re eating
primarily for social entertainment. That’s the only reason, right? They think they’re eating for health. But even the ones in a lot of fitness thing,
they’re socially doing what all of their crowd is doing, right? And even with us, I don’t think we know enough
yet, to really optimize. I think we did a relatively good job of creating
a simple roadmap with the food triangle. So, I think it helps from that perspective. We can say, “eat right.” We can say if you’re a bottom feeder, which
would be meat and potatoes, pasta and meat sauce, fish and chips, burger and fries. That’s the most energy dense diet you have
and it isn’t surprising everybody gains weight. Now, the fat people will blame the carbs,
and the carb people will blame the fat. And they’re both right for the wrong reason,
which that’ll be explained on the paper. But, that food triangle becomes a roadmap
and then the question is, how can we optimize eating frequency? Because I want to maximize my body’s chance
to do this and obviously, I could have fasted, and supplemented. There’s no reason why you couldn’t do that. Although, at what level of supplementation
do you interfere with one of those other systems, right? So, we don’t know that. But I think there are things that we should
be doing, but because there isn’t an economic endpoint, it’s a health endpoint, us getting
the funding to do that sort of thing becomes problematic. [Rhonda]: That would be an interesting study. I like this. They’re good, the meal frequency. I’ve seen I’ve looked at a lot of studies
on intermittent fasting, dietary restriction in humans and finally figuring out like why
a lot of the data wasn’t being replicated in humans that was found in monkeys and mice. And then, they figured out humans, when they’re
dietary restricted tend to eat more protein because it’s more satiating. And then, they’re like, “Oh, so then their
IGF-1 levels are going high.” You know, eventually those things will sort
of teased out… [Ray]: right, but even down the satiation. Okay, so that’s a made-up word. And the entire context to that word is used
in talking to people in a chronically veg state. I’m satiated. [Rhonda]: Yes, you are. [Ray]: Right. So, what I’m saying is if we’re going to change
the language, we have to fundamentally…as scientists, especially, we have to disengage
from all of those studies. They’re all polluted. It’s like, today, if I’m going to do a cholesterol
study, I can’t because there’s nobody out there that has the issues that aren’t on statins. The once we did before, are about the best
we’re going to do because we can’t do a randomized control and put someone and say, “Just don’t
do what you’re doing.” And the other guys, “Do this.” So, we’ve polluted the data set. All the studies are varying proteins, carb,
and fat. A thing that I want to get rid of. Well, okay, so I’m going to hold protein constant
at 12% and so in order to do that, what am I going to do? I’m going to study sugar versus oil. Okay. What have you just learned? Nothing. Because if I add a whole food, starch, I screw
up my protein number. If I add legumes, I screw up my protein number. If I add any of the things that I would actually
really eat, I screwed it up in the fat side. Okay, you add lots of meat. You’re screwing up your protein number, whatever. So, what everyone’s arguing about, the sugar
versus fat crowd, the whole crowd, if you really look at the papers, it’s pretty easy
to see. They’re basically arguing of that. And you can look at any arm of the study,
it’s really a simple thing to just look at the study and say, “You know what? I’m not even going to think about this.” Look at the carbohydrate arm, and you need
to see two things. First, did the fat go down? Not this goofy study, where a low-fat diet
is 40%. And say, “Oh, well, yeah, that’s what they
ended up eating.” Well, no, if you’re going to control it, control
it. You and I can’t say, “Well we’re aiming to
get 4 millimolar. But the lab tech just couldn’t get it right
and got it at 20 millimolar, and so therefore, we’re just going go with that.” And still call it a study. It’s just ridiculous what gets out there and
published. But, if we look at it, on the carbohydrate
arm, always, you’ll see a rise in the carbohydrate arm and you won’t see an increase in fiber. And if you don’t see an increase in fiber,
that means they added refined sugars… [Rhonda]: Yeah, that’s what it means. [Ray]: It means it’s just…compared to what
you and I eat, it’s an irrelevant study, I don’t really… I mean, we don’t need to debate sugar versus
fat anymore. It’s irrelevant because I don’t eat oils nor
I eat sugars because I don’t use the energy without the food. [Rhonda]: So, you can get whole foods, real
food. [Ray]: So, all of my foods, all of my dietary
sugars, all dietary starches, all of my dietary fats are all come from whole foods. For example, if I didn’t have the word… If we could eradicate the word carbohydrate
from the diet, just that one. Think about it for a second. If I don’t have the word carbohydrate, I can’t
equate a whole food starch with the refined sugar. There’s no way to connect them. I can’t equate a carbohydrate to this cotton,
also a carbohydrate. [Rhonda]: I always say refined carbohydrates. [Ray]: Yeah, but even if you say that, you’re
still not saying specifically. This is a carbohydrate, the wood floor is
carbohydrate, termites eat wood, moths eat shirt, cotton, linens, you know. What I’m saying is these are all carb. Chitin in crab shells, carbohydrate… [Rhonda]: That’s a vague term. Yeah, it’s not very specific. [Ray]: So, it doesn’t mean really anything. Then we got to start saying complex carbohydrates. What the hell? Now, we’re just making the language. This is nutritionism. [Rhonda]: We’re confusing it. [Ray]: We’re confusing it and yet, when, if
you do a study and say, ” I added potatoes and this is what happened. I added beef and this is what happened.:”
You know, instead of a protein source because for most… [Rhonda]: I added Twinkies and this is what
happened. [Ray]: Yeah, this is what happened. Exactly. So, the point I’m making is, is that it makes
more sense because the labels are just confused. We have the eat more, eat less policy in the
United States. It came out after the McGovern report, which
basically is when we’re going to say something good about food, from a government’s perspective. “Eat more fruits. Eat more vegetables.” If it’s something that’s bad, we’re not allowed
to name the food. “Eat less saturated fat. Eat less oils. Eat less refined sugars.” We’re not allowed to say the food. And from a government policy level, that’s
really what we do. And that’s what happens in the messaging to
the public. And you look at all across the agencies, they
all use that message. [Rhonda]: Do you know why that is? What was…? [Ray]: Because they devastated the beef industry
when they said don’t eat red meat. To this day, everybody says red meat. And there’s really not that much difference
between any of the meat. They’re all right about the same. We’re all animals. Now, if you report the calories per weight,
yes. I mean, I’m sorry, the fat per weight, it’s
the same. But if you report fat per calorie on all the
different cuts of meat, we’re all between 25%, 30%. We’re all really…there’s no lean meat. They’re all about the same. I mean, they’re very, very close. And so, that again, we have 26, 27 national
institutes for health, but nutrition is controlled by the USDA. Do I need to say anymore? I left NASA because I knew they weren’t getting
us into space. You know, that wasn’t going to happen. NASA is a great organization, a lot of smart
people there, everybody wants to do stuff. But in a mature bureaucracy, there’s a rule
against everything. So, getting back to our stuff, what I’m saying
is that if we would change the language and talk about food like all the things that you
talk about on some of your videos that you do, the short videos like your smoothie or
whatever. Yet, you’re talking about what’s in it, but
you’re always putting foods in it, you know. I don’t see you dumping powder in anything
you’re doing. And I don’t either. I know we’ve talked about this that night
we talked. So, if we start it with the whole food diet,
and we say, “Okay, we got a whole food diet. Now, how much do I need to meet my minimum
energy needs.” I mean it, if I’m active, I’m going to have
to eat more. If you’re in the baby producing time, and
that’s what you guys are trying to get pregnant, you’re going to have to definitely eat a different
diet. But then, how do we deal with that whole meal
frequency and eat in a smaller window to address this fasting? Or do we need to go a couple of days? You know, I mean, I don’t think anybody can
answer these questions right now. [Rhonda]: Well, that’s what I was wanting
to get to with the, what time frame do you need to fast to get specific benefits? And the specific benefits that I really am
interested in is the increase in the autophagy, which then increases hematopoiesis, you know. These processes are very important for long-term
health and something that I’d like to sort of tap into. And from the Valter Longo’s research at UCLA,
at least in animals, in mice, he’s shown that it takes 48 hours of intermittent fasting
to activate that whole autophagy system robustly and to increase hematopoiesis. So, now, whether or not that’s applicable
to humans or if there’s, you know… I don’t know and I’m trying to get in contact
with him to figure that out because I’d like to know. Do I need to do, incorporate 48-hour fast
to get those autophagy benefits that I want? [Ray]: Yeah. And this is my goal post book. I’ll get my book out there just because I
want to get sort of the language change, how we’re talking about food. To be able to get more people like us that
can extract the social paradigm which is, “I don’t care if you think what I’m doing
is radical. It’s not biologically extreme and there’s
a lot of different benefits.” And studies that are starting to be… I want to see studies that are done that don’t
use the template of three meals a day, you’re going into starvation mode, we’re gotta make
sure you get every single thing, you know. We got shot down by an IRB, it was embarrassing. But we got shot down by IRB, I won’t say where,
for me to eat potatoes for two weeks in a metabolic lab. Because the IRB said it wouldn’t be nutritionally
sound. [Rhonda]: Based off of? [Ray]: Nothing. Okay, now, never mind. I had a better calorimeter than this major
Ivy League school. Their IRB didn’t want me to do it. You know, we were going to some full comprehensive
blood work, something that we could, at least, write up as a case, something that could be
a seed to get some funding. But that’s how polluted it all is. [Rhonda]: It really is. [Ray]: And you talk to your average dietician
and now, the protein, carb, and fat. I mean it just becomes just jabberwocky. [Rhonda]: I personally just want to like figure
out the best diet that…what I can do right now to extend my healthspan. And right now, I’ve been turning to what’s
known. I’ve been looking at these supercentenarians,
which I know there are individuals out there that are 115 years old and are cognizant and
are healthy and are still active. They’re not like this crippled and you know. And so, I want to look at these individuals
and understand what it is about their genetics because we know that things like intermittent
fasting, dietary restriction. We know that hormesis, different plant compounds
that are present in a variety of plants, can activate a variety of genes that maybe activated
in these individuals. We know for example FOX03 is one that’s well
known to be associated with… [Ray]: And that’s Luigi Fontana, I mean, he’s
big in [crosstalk]. [Rhonda]: Right, exactly. And so what can we do with our diet, with
our lifestyle that can activate these different pathways to help us to live longer. But to get on that, sort of on that note… [Ray]: So, temperature…cold [Rhonda]: Yes. So, temperature, so there’s a whole like… [Ray]: Tell me about Wim, first of all. So, I know you’ve interviewed him… [Rhonda]: It was fun. [Ray]: …but tell me all that. Isn’t he an amazing man? Interview: He’s full of energy and passion. We had really a fun time hanging out. [Ray]: A couple years ago, I went over for…and
we spent a week together just to get…before everything was on a rush, he was like in a
what-is-he-gonna-do-next phase. And we just spent every day just talking all
day and night, that we’re lying in beds and we’re in the same room, we’re just having
these conversations. It felt like at camp when you were a kid,
you know. You’re lying there in the dark talking about
stuff, hearing all these stories. What was really fun about the whole thing
is that as I was… You know, I went out, I usually carry just
the gloves. I use these the Agloves. They’re really Agloves but there’s silver
on them because you use it for iPhone and they’re just little cotton gloves and I use
these little ear bags. If I have those, if I cover those two symptoms
up, I can tolerate cold really well. So, I have my gloves on and I’m out walking
and then… [Rhonda]: Where are you guys? [Ray]: We’re in Amsterdam. [Rhonda]: Amsterdam, in winter? [Ray]: Yeah, it was like February and we’re
walking to the grocery store and we walked down and he walked down. And he wants to strip down and get into the
water, cold. He’s just this way. It’s just fun. We had a great time. So, we’re walking back and he’s looking, he
was, “Ho, ho.” I think actually, “Look at this. The Ice Man has a coat and you have a short-sleeved
shirt. This look crazy.” Then, like, he took his jacket, he’s “I need
to…” And when we got home, he opened all the windows. He said, “You know, I’ve been trapped in this
apartment all summer.” But it was really interesting that people
think of him and you see this. People think of him as an extreme and what
Wim’s actually trying to say is not extreme. He’s saying, “Humans can do this.” We can. A normal human can do it. This is what I’m saying now about fasting. A normal human, I’m not a superhuman to go
without food. This is normal. And normal humans experience it. And what’s interesting is, just like this
time with that and what we have in our metabolic winter hypothesis paper is this the fact that
these two traits, cold stress and dietary restrictions, hit the same genes, hit the
same UCP1. Hit the same PGC1 alpha, you know. [Rhonda]: There’s overlap, yeah. [Ray]: Yeah, there’s overlap and you know
that winter never comes. There’s never time of cold stress, there’s
never time of dietary restrictions, scarcity, and we’re in a chronically-lighted environment
because of modern lights. So, if we think about this the idea, unfortunately
gets, you know…the cryotherapy. And you know, I got to be…and it’s all get
sold as extreme. But what you found, like in your sauna thing,
I don’t know if you’ve talked about on another blog or whatever, but the idea that suddenly
you get this amazing sleep, like, amazing sleep… [Rhonda]: Well, I didn’t. So, recently I had this experience where I
had done some very extreme temperature contrast therapy where I was sitting in a very hot
sauna, at its peak it was 220 degrees Fahrenheit, which is very hot. And then, transitioning once… I mean, I was bearing the pain, I was sitting
on this hot sauna and really pushing it. Like, I wanted to get out but I stayed in. And then, finally, I got to the point where
I’m like, “Okay, I’m going to get out.” And then I went straight into an ice bath,
a very cold ice bath. I mean, it was just lots of ice. And that was also a very difficult because
it was cold. So, I was going from, like, hot as a hell
to, like, really cold. And that was the first time I’ve ever done
that. [Ray]: Did you notice the pain sensation on
both sides was the same? [Rhonda]: Yeah, it was burning. [Ray]: Yeah, it’s interesting. We only have one sense. [Rhonda]: Well, what’s interesting, I met
with this… Okay, let me get to the sleep thing. I’m going to get sidetracked like I always
do. But, so, I did this, like, four rounds and
I had a variety…I mean, I noticed I felt really good, really relaxed there’s a lot
of things going on the brain. And I’ve done the sauna for years. And the sauna also makes me feel really good
and I talked about some of the mechanisms why that occurs. But the way I felt with the contrast therapy
was a little different. I felt extremely just very relaxed and very,
very happy and pleasant. And I’ve done cryotherapy. And cryotherapy also, where I was standing
in a chamber with liquid nitrogen, I also felt really good, like, after doing that for
two or three minutes, if we’re at home, and I did for a bit. And I got a…and it felt good. And I know that’s norepinephrine is being
released. It’s been shown with cryo and cold-water immersion. But anyways, back to the contrast therapy,
the thing that was so surprising to me was the fact that it completely reset both mine
and Dan’s circadian rhythm, where it usually, like, him more than me, we’re kind of night
people. Like, I go to bed before midnight, but he
struggles to go to bed before midnight. And so, we were a bed at 9:30 p.m., so we
did this in the evening. So, we started at like around 6:00 p.m., I
think. But by 9:30 p.m. we were in bed and asleep
by 10:00. And we woke up the next morning at 7:30. And that is not our typical schedule and certainly
not his typical schedule. And that was very surprising to me, the contrast
therapy, resetting my circadian rhythm. [Ray]: So, one of the things you asked earlier
about cold stress and weight loss with people I work with, that’s actually one of the things
I do. I want them to get a lot of sleep. So, I talk…I have sort of more of a metaphor,
I guess, I use to sort of simplify things. But metabolic winter, I think of dark, cool,
still and scarce. Metabolic summer is bright, warm, active and
abundant. One of the things that I want them to do is
get a lot of rest, Like seasonal affective disorder. Is it a dysfunction or is it a feature? Because if you’re…don’t have a lot of food,
it’s really not worth to die. The idea that we’re running through the spears
and getting stuff is a bunch of cartoon stuff. I mean, the idea was we would just hunger
down, we would wait. And interestingly, the first plants that we
see, the first green that comes up to the ground are all attached to bulbs, starch,
underground storage organs, which is kind of an interesting, easy way to find them. But the contrast therapy, so I have them do
10 seconds of warm, 20 seconds of cold. I have them repeat that 10 times. And then, end on cold. Now, at first, it shocks… [Rhonda]: This is the shower? [Ray]: Yeah. It’s a contrast shower. And it sucks at first. [Rhonda]: How hot is the water? [Ray]: Just your…you just need to get warm. [Rhonda]: Just warm, okay. [Ray]: So you get either a Gymboss timer or
get the app on your phone and set it up for, like, a tap app would be. You know, 10 seconds, 20 seconds, and repeat
10 times, end on cold. [Rhonda]: So, 10 seconds warm, 20 seconds
cold, end on cold. [Ray]: And Wim and I, we developed this, literally
in his apartment. We were talking because we were talking about
the benefits and we were talking about the saunas. We were talking about that. But what we do in a concise amount of time
that would get us going. As a complete coincidence, just like you,
I was doing something, I don’t know, we are…or whatever, it was late and I was still going. My mind was still going. And I went and did that and I realized I’m
really getting sleepy. And so then, I started repeating it and it’s
like, “Wow, I get sleepy really fast.” I hit the bed and I go to sleep really quick. So, at first, because our our skin can’t sense
absolute temperature. We sense differences, in fact, Wim did a little
finger, one little finger task and they made them with ice water, he passed out, which
is kind of funny because he said, “Did I die?” You know, the Ice Man passes out, submerged
my body in ice and they did this little test. And there’s this strong, I don’t know what
they…I haven’t looked it up, but there’s some strong react…something they do with
your hand and it has a strong response and it can make people pass out. So, anyway, but the point is, our body sense
differences. And I wrote a blog about this online. It’s called, Ch-Ch-Changes. And the body really, like, if you’re out working
in the fall, and when you go out, it’s cool and start raking leaves or you start doing
something physical and then you take off layers, and now you’re fine or whatever. And then you walk in the house, “Ah, it feels
hot.” Right? And you say, “It feels hot in here.” And everybody else says, “It feels normal
in here.” You’re turning down the thermostat and vice
versa walking. So, we sense these changes and so what we
try to do is make it practical where we can do it. And what I’ve found with myself and with hundred
or so people I worked with is that, do it again in the morning, it just lights you up
like a Christmas tree. You just feel ready to go. You get out and go,whooooo , you know. You’re ready to go. Not a cold shower, but the cool… [Rhonda]: The contrast. [Ray]: And then, there, you can go as cold
as you want. You have to have a big contrast. At first you might not go as far, but eventually,
you’re going to full cold because it’s not… I mean, it’s like 50, 55 degrees. You’re can handle it. Everybody has a part, their belly, their back,
their face, something about them really makes them, like tighten up. But you’ll figure that out. And what’s paradoxical about it, and I saw
this on my blog and people reporting back, this is all a couple of years ago, was that
you start tolerating heat better too. And it was kind of weird, you start sweating
less. Your body starts getting sort of more adapted
to this contrast so that when you go from one environment to the other, you just doesn’t
seem to be as much as stressed, which means, when you go out walking, when you go outside,
I always have people do the reserve of skiing. So instead of layering and taking them off
as the day goes on, I say, carry it with you. And only put it on if you really need it. You know, cover your symptoms first. You know, we don’t get a frostbite of the
head. We get it of the nose, ears, toes, fingers,
the extremities, right? Basal constriction happens and when basal
constriction happens, we start to losing the circulation, if it’s cold. But if you cover those symptoms first and
that was my very first experiment I did, before the first weight loss, I say, “Why am I cold?” And just sitting out in my back porch with
a notebook trying to say, “Okay, how do I stay out here until I can’t stay out here
anymore? What makes me go back?” And what I found was my ears and face will
send me into, “I can’t stand it anymore,” way more than my body. So back to the contrast showers, what doing
this contrast does is it slowly elevates your tolerance for cold, like, right now, I have
zero cold tolerance because of the fast. And I opened my windows last night, and it’s
even at 66 degrees, which my house is normally colder than that, it’s starts really feeling
really cool. You know, that’s just a temporary thing. And last time, I took about a month and a
half or something to where my normal cold tolerance came back, I know it pretty well. But as you do this contrast therapy, and you
end on that cold for two minutes, again, in the morning, it gets you alert. And at night, because of that, I think, where
you are in your circadian day, it makes you asleep. And I did the same thing in Australia that
you did from your term, to reset. And then I tried it. Now, I didn’t get completely over jet-lagged,
so it wasn’t really a complete success. But I used a combination of melatonin and
those mild cold stress, and light, you know. And it still took a day or two. It’s worse coming back, for me. It was much worse coming back. And I didn’t completely fix it, so there’s
obviously a time function that we sort of can’t avoid. But, I think something is simple as that has
benefit. [Rhonda]: Yeah, I’m definitely going to try
to dig into some of the mechanisms there because it’s…and it’s hard to find, but I’m planning
on trying to understand just because it’s profound for me. [Ray]: And there’s really good data. Maybe I could find a Dropbox folder and send
you. I’ll send it, like… [Rhonda]: Please send me anything. Yeah. [Ray]: I’ll send it, like, but, like, on clinically
depressed patients. We’re doing 5 minutes cold showers with 60
degrees F. And they were having as good of results with medications with their depression. [Rhonda]: Please send me that because I’ve
been theorizing that that would be the case based on the fact that cold, if you’re, I
think it’s around 60, anything below 62 or 63 degrees Fahrenheit, 17 degrees Celsius,
whatever that is. It increases norepinephrine and that’s… [Ray]: So, mild cold stress, when I talk to
people, first of all, I don’t think people really don’t need to be doing ice stuff right
now. I mean, it’s just, there’s way more risk and
you can get a lot of benefits above it. So, what I always tell people, because I think
everybody goes to the extreme and the fitness industry is the worse about this. But basically, the guidelines I give to people
is this, it’s that mild cold stress begins at 80F in water, okay. And it begins at 60F in air. So, that’s where you start seeing a change. You start seeing a metabolic response, you
start seeing a hormonal response at about those temperatures. Water is really easy to deal with, all the
way down to 60F, when you get a little bit below that, it starts hypothermia and walking
hypothermia is a real problem and you can become hypothermic and not really know it. Because that shivering response shuts down
and you go into your non-shivering thermogenesis. And, yes, you boost up, you can get 300% to
500% increase in metabolic rate, and you can measure this, which I can show you some stuff
later that you can actually measure it, and a shift in respiratory quotient towards what
we want to do, which is fat burn. But, it also, the risk of injuring yourself
goes up greatly. So, my caution to everybody is to play in
the mild places first and then go down. With air, if you’re above… [Rhonda]: Can you send me the studies on the
risk of injury as well? Because I didn’t… [Ray]: Well, hypothermia is all of the device. There’s basically a chart. But if you look at the chart, and I’ll show
you what it is. If you just put water in hypothermia, you
can get a chart and there’s an exposure time. And now, obviously, I can exceed that by far. And Wim can exceed it by far. You can train yourself to do it. What I’m saying is, you get the person out
there. They get all excited. They start extreme and then they wind up having
a problem. So, and the air one is below 32. Below 32, you start having a big risk. If you work in the range of that, of 60 to
32, or 60 to 80, you pretty much, for a normal person, you’re going to do just fine. Now, for swimming, because one of the things
I want to do, this is the last time I’m ever doing weight loss stuff. I’m done with this forever. So, I’m actually going to start exercising
and I haven’t exercised for five years now, only cold stress. Yeah, so all of this kept, even after five
years. You know, all of my muscles actually shrunk
now, which is kind of weird to look because the volume of water that leaves your muscles
when you’re fasting. It really freaked me out last time. I was like, I just was sure that I was just
atrophying like crazy. I was really, like, “I’d really screwed this
one up.” When I get back the DEXA scans, as soon as
you start eating and getting minerals in your diet again, sodium and other stuff, the water
comes back up. You know, like, for example, when you pump
up in a gym, you’re not adding protein or amino acids, you’re just adding fluid. So, anyway, but my point is, it’s that, I
stayed fit. I kept muscular and I did it all through cold
stress. I just did cold stress. [Rhonda]: Okay. So, what was your protocol? [Ray]: So, the contrast shower is one of them. I also have a 8 by 16 swim spa that I put
in backyard. And I have 110,000 BTU heat pump on it. So I can take it to 45F, all the way up to
a hot tub. My kids love it they have a his or have a
party, it’s at 102 whatever. And so, a regular cold exposure in there,
and I would just lounge. I mean for example… [Rhonda]: Shoulders under? [Ray]: Right, up to face. In fact, I did a thing with Steven Leckart
from “WIRED.” When he came, we did all kinds. I’ve got great data from him, but we did feet,
I think, knees, waist, shoulder and head, when we’re he was always submerged. So, I was doing metabolic rate the whole time. [Rhonda]: What temperature was the water? [Ray]: Sixty, I did him at 60. I did him at 70. I did him at 80. [Rhonda]: And those were essentially the same
between all three temperatures? [Ray]: No, there is some differences. And then also, I did…and a lot of this is
on a blog. I think it’s called… What did I call it? If they just go to the metabolism tag, I came
up some stupid name for it, but it’s something metabolism, Mastering Metabolism or something. Anyway, I’d do it in the third part. I talked about Steven’s results. And then down at the comments section, I posted
even more data because people became interested. I don’t want too much of it up there just
because it gets boring. But the swimming, getting back to swimming,
I want to take up swimming. No, I’ve always been able to swim so I’ve
never been afraid of water. I scuba dive, I was a water skier, I love
swimming. But I never learn to, like, swim laps, you
know. And I really want that graceful, to be able
to swim. So to me, the only exercise you can start
at age at any level of fitness, and you can do it till the end of your life. So, I want to introduce…and what’s interesting
about resistive swimming, which means if you’re swimming on a tether and you’re swimming in
a swim spa or a tether and a pool, where you just have a mount, so you have like a fiberglass
rod and a rope that goes through a band. When you’re swimming, it’s really glide left,
glide right. You know, you’re basically cutting through
the water. It’s not really a power move. You know, it’s really about the hydrodynamics
of the water streaming over you, you know. But when you’re swimming on a tether and you’re
not moving, it’s like slugging through water. So, it’s actually physically more difficult
to swim on a tether. It’s the same activity, the same feel, but
when you move, you start moving that fiberglass rod and you start bending it down some. And if you let off a little bit, you start
going back. So, you actually, it becomes… even swimmers,
really good swimmers, have told me, I had Olympic athlete in my pool, and she said “It
really definitely gives you work out.” If you want the workout part. But what’s really amazing about Steven’s data
is that when he got out of the water, instead of doing what everybody does and jumping in
the sauna, we just had him sitting there. We were measuring his metabolism the whole
time. And his respiratory quotient went from 1.0,
which is most activities are burning glycogen, almost to 0.7, almost pure fat. And for over an hour, he was still burning
fat. [Rhonda]: And that’s after what temperature
being on the water? [Ray]: That was 70. [Rhonda]: Seventy. [Ray]: So, for swimming, the optimal temperature
of comfort and impact is about 75F, with all the stuff I’ve looked at, not to study, the
stuff I’ve looked at my pool. Right around there, it’s too much of a shot. Now, 70-degree water, for someone who lives
on the West Coast are like, “What?” You know, right? [Rhonda]: Right, that’s what I’m thinking. I sort of… [Ray]: If you live in the South the Gulf of
Mexico is like 80, you’re in the tropics, and down at 60, it starts becoming something,
right? [Rhonda]: What do you mean by becoming something? Like your metabolism really speeds or you’re
like burning fat? [Ray]: No. You’re still going to burn carbohydrate as
long as you’re really active. And if you’re shivering, you’re burning carbohydrate,
you’re not burning fat. Shivering is exercise. So, here’s where we are now, we talk about
this little bit, the metabolic winter. Our body, which is… You know, I believe exercise is mimicking
cold stress. I believe most of the benefits that we’re
seeing because here’s what happens. If I have people exercising and they start
to shiver, I’m sorry, sort of exercising, not shivering, they start to exercise, they
produce irisin. Irisin is known to up regulate and create
more brown adipose tissue. We’ve seen these studies and it’s come out
in the last three years or four years. With shivering, shivering is the original
exercise. I mean, we don’t really have to go do something
at the gym. I’m not talking about people that want to
look better. I have no problem with people having it in
as a sport or compete, competition or whatever. Our conversation is in the silo of longevity
and healthfulness. You know, this is metabolic. So, the first step of cold stress is that
I’m shivering. Now, this is a very energetically expensive
way to produce heat. Why? Because now 20% of it is being used to move
the muscles and do that. So, then what happens? Little bit later, shivering stops, non shivering
thermogenesis kicks in, up regulation happens, you see if you’re 1. Now, I’m just using electron leaks through
mitochondria and suddenly, I’m not producing my ATP, I’m just producing 100% heat. What’s the cell used to do that? It’s grabbing the most energy-dense fuel,
and it’s using lipids to do it. So that’s a real good adaptive strategy. Because if you’re keeping warm using glycogen,
you’d run out, perishes quickly. Or if were using it and it was coming from
gluconeogenesis, you would run out really quickly. So, what’s interesting is that if you think
of exercise is a way that we mimic mild cold stress in the past or periods of mild cold
stress. A lot of the benefits might actually be the
same. [Rhonda]: Yeah, I think there are definitely
a lot overlapping benefits like the brown adipose tissue, PGC-1 alpha, increasing mitochondrial
biogenesis all these, fat oxidation. [Ray]: They all overlap. [Rhonda]: But there are absolutely important
benefits from exercise like… A study, just I was reading today, about on
the brain how it’s like doing aerobic exercise in midlife for a mouse, like, prevented the
blood-brain barrier from breaking down, prevented, decrease the amount of activated microglial,
all… So there’s a lot of other benefits from exercise
that did not related to… [Ray]: The point is here, and this is about
changing our conversation because it almost is impossible to talk about something other
than exercise without someone saying, “Yes, but exercise…” Forget that. We all know there’s benefits to exercise. Let’s just put that aside for a second and
let’s say, “Okay, what specifically might be going on? What specifically…” The same people probably didn’t study the
same people that were in mild cold stress. And maybe some of the same benefits can happen
with that. So, all I’m saying is that it’s possible. You can’t prove right here. But it’s possible that a lot of these benefits,
of these excess moving, because in nature, all organisms are conserved or they conserve. They live a conserved life. We want to think of them all active and they’re
on the hunt. And they’re more active than us and we live
a sedentary, our lifestyle. But the opposite of sedentary isn’t exercise. The opposite of sedentary is active. And I didn’t say I wasn’t active. I never said I never got on a bike. I just didn’t changed clothes to do it. I didn’t say I didn’t never got one of the
kids for a walk, I didn’t say that we don’t go…I’m a skateboarder. So, I didn’t say we didn’t longboarding. I just said I don’t, I didn’t count it. I didn’t write it down. I didn’t do it. [Rhonda]: You’re not going to a gym. You’re not like… You’re not this… [Ray]: So, what I’m trying to say disruptively
is, “Wait. Let’s stop talking about exercise for a minute.” Because these all got started in around 1911,
between 1900 and 1911. McFadden was the first one. I’ll show you the books when all these got
together. And the link of diet and exercise primarily
through the calorie. Now, we since learned there’s a lot benefit. But the vast majority of people think it’s
energy. I’m outputting energy and I’m inputting energy
and I’m trying to maintain that balance. And that’s really not the way I’m thinking
of exercise. I’m thinking of exercise the way we think
of food differently. So, we are on the same side of that. And I’m saying that there are things that
exercise does that might likely mimic cold stress because exactly the same thing happens. It doesn’t make sense for the body to create
irisin that creates a tissue that burns fuel and just creates waste heat. Unless it was more energetically do it. It was more energetically to get up and move,
to migrate the waste heat, to go get something. That would have probably been the pathway. I’m saying there’s a good argument to be made
that maybe the benefits are that we evolve those sets of cold stress responses to happen
to mimic the dietary restrictions as a survival mechanism for winter. And we’ve just engineered winter out of our
life in the last century. [Rhonda]: We do have temperature-controlled
environments that are, you know… And I think that both temperature extremes
are important. And if you’re living somewhere, like, in the
South, it’s hot as hell in the summer and winter is cold maybe that’s the way it was
supposed to be. Maybe, your body is supposed to be shocked
by the heat and shocked by the cold. But instead, we come into this heat and air-conditioned
houses and, you know… [Ray]: And what you said it, when we were
talking to the party, we’re sort of making our literal mind meld implosion in the center
of the room, right? You know, I think we sort of forgotten everybody
was there, we’re… But the heat shock proteins, they’re very
similar to the cold. So, the point I’m saying is, if we could just
entertain the thought Aristotle said it’s a mark of the educated mind to to entertain
the thought without embracing it. And I’m saying, let’s put exercise aside for
a second. Just like I’m saying, as soon as I talk about
calorie restriction, intermittent fasting, fasting, immediately, the dieticians go, “Yeah,
but you got to have balance. You can’t be deficient.” It’s like, “Okay. We understand that that’s there. We don’t want to talk about deficient. We’re not talking about deficiency.” But they don’t even know the concept, they
don’t even know an idea behind how a person would possibly even live… They think you die in days without nutrition. They just, they do. And it’s funny, right? And yet, I’m having this is a pretty challenging
conversation. And it’s today, 23… [Rhonda]: Yes. I have a question. [Ray]: Go ahead. [Rhonda]: On your 21-day fast, like, so what
happen to your bowel movements, like… [Ray]: They stop. I still haven’t had one. [Rhonda]: Like how long? [Ray]: The last one had was Monday at a 7-11
on October the 12th. [Rhonda]: And today’s November 3rd. [Ray]: I haven’t, yeah. You just don’t have them. [Rhonda]: That’s pretty wild. [Ray]: Yeah. It’s crazy. You don’t have bowel movements. [Rhonda]: Could you please do a uBiome, Like,
I want to… Oh, you didn’t do it before. [Ray]: Dammit, I know. I wanted to… [Rhonda]: Oh, Ray, what’s wrong with you? [Ray]: I just have so much to get…I just
had so much other. I mean… [Rhonda]: That would have been so interesting. [Ray]: All the blood work I did was so expensive
and I’ve used really donation on my blog. You know, there’s plenty of opportunities
to do this again. You’re absolutely, well, I should have done
it. I should have done it. And the last time, in the nitrogen, I forgot
to do nitrogen. I didn’t do nitrogen the last time. I had dexus. So this time I did nitrogen. So, I have that. But anyway, getting back to cold stress. The point I’m making is that this is what
I mean about changing dialog. And what I’m trying to do in my book, “Our
Broken Plate,” is talk about how we can separate these. I got a chapter on exercise. Look, okay, I’m starting this all. Exercise has a lot of benefits. Okay, did we get that over with? Okay, I don’t want to talk about that anymore. I want to talk about were exercise overlaps
with this really cool, really…pun intended, I guess…cool things in our biology that
are connected with longevity. And it’s like extreme. Okay, I know we can live in extreme environment. We can deal with all extreme stuff, but quite
frankly, I don’t have this testosterone rush. I don’t have to beat my chest and say, “You
know, I’m the he-man with the abs.” I just really, really care a lot and I want
to live long. You know, they can have the abs or whatever
they want. So, the point I’m making is what I want to
do is look at this cold stress and say, “Okay, look, here are all the things that we know
are up-related. Here are all the things that happen. Yes, they have an overlap with exercise. And then, over here, we’ve got nutrition. And there are things that we need to be nourished
with and things we don’t want to be deficient in, but here’s where we have dietary restrictions.” And I think that something can be put together. And then you add the third part of the trichotomy,
which is sleep. It’s clearly sleep is beneficial for both
those. So if we look at this little trichotomy. It’s sleep, cold stress, and dietary restriction. To me, that’s the axi we start with. And then, the exercise, again, just like we
talked about with starches and sugars earlier with the studies, all the exercise stuff,
a lot of it is done on people that are living in a normal world. So, if it makes you better in a normally overfed,
overnourished kind of world, that doesn’t mean people that have actually are approaching
diets like you and I care about our diets and we’re approaching something, at least
the best we can figure out, approaching something that’s optimal, if it’s necessarily going
to have the same benefit as us. It might drive overnutrition because there
is a feedback loop. There is a point, there is a tipping point… [Rhonda]: I’m just in my head, thinking there
might be a temporal effect too because I’m just now, I’m recalling a study. So, this animal study I just told you that
it was just published in FAS Journal, I believe…Maybe it was “Plus,” it’s one of the… I’m sorry I don’t know which journal. But it was published like today where they
showed that in midlife aerobic exercise had all these positive effects in your brain,
delayed markers of Alzheimer’s and all of those stuff. There’s another study, though, it’s published,
about last year in “Nature” that showed that cold stress, it was mild cold stress, actually,
it’s more than mild because it’s more like standing in a refrigerator for 30 minutes,
so it’s cold. [Ray]: Right. Every two hours. [Rhonda]: Yeah. But it showed that mild cold stress protected
against Alzheimer’s disease in animal models that were genetically engineered to get Alzheimer’s,
human Alzheimer’s. It showed that it protected against it but
only if the cold stress was done in early life. So, if cold stress was done in midlife, and
not in early life, it had no protective effect. So, it was kinda weird, and I’m not exactly
sure why. But, I do want to ask you on the cold stress. I would be interested in seeing the studies
to see if there’s synergistic effect on the brain. I’m also very interested in the brain and
effects of exercise in the brain. [Ray]: Most of the work that I did on cold
stress, because where I was in that point in my life, I didn’t understand calories. And so, I was really trying to understand
how can we maximize calorie burn. I really believed the goal at that time was
to create more metabolic output. And I hadn’t quite found that I can control
weight and everything perfectly with the dietary input. It’s actually pretty trivial. So, now that my goal has flipped, so a lot
of the things that I know about these are ancillary to what I was looking at at that
time. But I’ve aggregated a lot of studies on that. So, just, it would be a great day to dump,
when we go back, I’ve got a lot of them. Unfortunately, I have to have paper when I’m
reading a paper. I can’t do it online. I can’t do it electronically. Maybe with the new iPad. [Rhonda]: Some people are physical, like,
do you remember things by physical… [Ray]: It was just because I did it that way
for so long. I always had notebooks, I always wrote, whatever. Maybe, with the new iPad Pro, whatever, it’s
big enough and I can right on the paper. Maybe that will give me enough tactile input
that I can do it. So, the downside is I’ve got all these PDFs
that are lost mentally… The upside is that I have lot of them organized
because they are paper. I have a lot of them. They’re in one place. We could just use data dump. But, I wasn’t looking at what you were looking
at. That’s the point. [Rhonda]: But I want to ask you about, like,
a protocol. Let’s say if someone wants to try to increase
some of their brown adipose tissue, they want to ramp up their fat oxidation in using mild
cold stress, is there some sort or general protocol where you say, “You know, spend…”
in addition to your contrast that you’ve mentioned. You know, you spend 20 minutes in 60-degree
water or something like that. Is there something that you think would work? [Ray]: It’s on my website. I actually have the data right there, you
can see it. I mean, it doesn’t burn a significant amount
of fat. That’s the downside. So, you’re not going to really… The weight loss is minimal. It does in addition to dietary restriction,
but you have to have some kind of deficit to start with. But it definitely shifts your RQ. And what I have seen is that generally speaking,
after a few weeks of cold stress and doing restrictive diet, where you’re just running
in a chronic deficit. You’re going to see your RQ shift more towards
0.7, it lowers, it goes more towards fat burning. You know, you can get yourself easily into
mode where you’re about 75% of your day is fat, is burning fat, metabolizing fat, if
you keep your activity low. As soon as you start doing things, it raise
your activity, your respiratory quotient starts going back up and then you’re on a glycogen
treadmill, which is why all these people want to get to ketogenic because they want short,
change this system. But I’m talking about something that also
benefits the microbiome, etc. And if I do that lifestyle, then the microbiome
is like pushing a bubble on a bumper sticker, you know. They’re just pushing the problem around, but
nobody’s worried about the microbiome. And that ends up being, I think, like, we
said earlier, that’s actually the most important place. That’s where we need to start. Feeding it, and make sure we get that, but
shifting it over to fat, you absolutely can with cold stress. Most people just don’t have access to cold
water, you know. [Rhonda]: What about just sitting in a cold
bathtub, like if you just put cold water and… [Ray]: Yeah, I think that. Again, what I do when I’m skiing, for example,
is because since I was skiing every year, but I wasn’t doing any activity or any training
before. Normally, what that would mean is like on
the second or third day, you will just be fatigued and your legs were wasted like noodles,
right, everybody would think. Yet, it never happened to me. And the reason why is as soon as I come off
the slopes, I go into the bathroom, I do a contrast shower, end on cold. The bathtub is already filled with cold water,
as cold as it would come out the tap, just sit up to my waistline in cold water and all
of that leaves. And you feel, when you get out, you’ve almost
feel as if is you could go run and do anything again right then. It just does that. So that’s like a little simple strategy that
I use for that. I moved past the calorie thing because in
order to do the calorie balance, I needed to understand food. And so then, when I get the calorimeter… Yeah, I did some things with Steven on activity
and all of a sudden it was like, “Wait a minute, it’s all the food. It’s the food. It’s the food.” Because no matter what I was doing, the numbers
that I’m in… When you’re really measuring your calories
and you’re really seeing exactly how much fat and carbohydrate you did in the session,
you can’t hide from it. And it’s like over and over and I’m like,
“Wait a minute. It’s the food.” So, that got me off from four-year rabbit
chase to figure out how that our relationship with food breaks. So to not answer your question, but address
it at least to say is that I don’t think I have it at that granularity. And I think, to me, where I am now, my interest
is really in how much cold stress do we need to activate these things. That’s where I want to go next with it. Next with, just like we were talking about
earlier, with crowdfunding and potentially doing stuff with dietary intervention that
we can measure these biomarkers, okay, then with and without cold stress, you know. I live chronically in cold stress in the winter. So, I let my temperature fluctuate with the
outside. My heat is set, maybe, at 50. So, it goes up sometimes because the day is
warm and you get whatever. [Rhonda]: Wow. That’ what night is, it’s get cold. [Ray]: It’s cool. Yeah, I don’t sleep… [Rhonda]: Fifties. [Ray]: And I don’t sleep with blankets. [Rhonda]: At all? [Ray]: No. [Rhonda]: You have sheet? [Ray]: No, sometimes I, yeah… [Rhonda]: At 50 degrees? [Ray]: Yeah, I can sleep… Right now, I can’t because of the fasting. But I conditioned myself. It’s one of the things I did before, all of
the stuff that came out in the “4-Hour Body.” I started with blankets and I’m like we had
blankets or we blanketed because we never use to heat bedrooms. That was blankets were for, the rest of the
house was cold. And now, we have blankets and we heat the
bedroom. So, I started with the blanket and I folded
it down. And then you’d have it back in the morning,
right? And then you fold down. One night you wake up, it’s “Huh, I didn’t
use the blanket tonight.” You know, it was halfway. And I found that if it’s just on my feet,
just actually the weight on my feet, and it turns out, I have enough. And you know, a lot of my friends are astronauts,
one of my friends is Scott Parazynski, and they talk about sleeping. A lot of astronauts can sleep free-tethered
and float. And a lot of astronauts needed tethered to
something because they need that feeling because they don’t like the the mummy free float thing. So, I’m a little like that and my feet needs
some kind of weight on them, and that’s funny. So, then I start with the sheet the same way. Put it halfway down, sleep without it, and
then you get it back up. And where you end up with is really an interesting
place. So, for me, the comfort you get from a blanket,
that this is like sugar feels good and food gets good, and that sort of thing. The comfort you get from a blanket is sort
of this warmness, womb-like feeling. That feeling for me is between me and the
bed. And when this side gets cold, I turn over
and that’s the warm spot, you know. [Rhonda]: But you acclimated yourself to the
[crosstalk]. [Ray]: But I acclimated. Now, have you ever taken a nap on the sofa? [Rhonda]: Yes [Ray]: Did you need to use a blanket? No. You can just sleep on the sofa. [Rhonda]: I don’t remember. [Ray]: But you know my point. People falls asleep on the couch all the time. You don’t need to do all that. It’s just conditioning. And so, you don’t just like put all your blankets
off and say, “I’m going to sleep without covers.” That’s crazy. That’s just like you’re not gonna… You got to do it slowly. And there’s a really simple test to see if
your room is too warm or you’re over blanketing. And that is if you stick your feet out from
the covers at night or in the morning, or you have to stick your hands out. If you do those two things, that’s a sign
that you’re sleeping with too much covers. Because that’s a way to trick your brain into
thinking that you’re cooler than you really are. Because we actually have to go to cool. So, on the melatonin, which is a natural place
everybody knows about melatonin reset and that sort of thing. And we can talk about the sirtuin and that
paper I sent you with the activation, which I think is good for the longevity stuff, but
one of the rules of melatonin is to have you drop… [Rhonda]: Core body temperature… [Ray]: Temperature through your extremities. [Rhonda]: You actually told me that. You’re the first person who told me that when
we met a couple of months ago. And I was completely fascinated and I looked
up the studies and I found… Yeah, and it’s strange, melatonin, it does
make their core temperature drop. [Ray]: So, what’s needed is this is part of
that, gotta drop the brain temperature. And what we do is we have this warm room,
we get in our warm pajamas we get in our flannels, we put this blanket on. Everything is antithetical to what our body
is trying to do. Now, enter the contrast shower. You start out with the contrast shower. Say 30 minutes or 1 hour or so before you’re
going to go to bed, right? Out of the shower, lights go off. Now, I’m into the…all these people walking
around, Blue Walker, Blue Walk… whatever, fuck, I don’t do that. Just come out there, lights go off. I have a little red light that’s…my bed
light is red and I switch to paper. The screens go off, and now I’m with my old
books. I love reading my old books, right? Okay. Thirty minutes I stay in the dark, and I do
about 30 milligrams of melatonin at night. [Rhonda]: That’s a lot melatonin. [Ray]: Yeah, it is. It’s a lot of melatonin. [Rhonda]: It’s a lot of melatonin. [Ray]: Yeah, it is. I do about 30 milligrams a night and there’s
a lot of really great stuff that was done in ’90s: melatonin, the antioxidants side,
and obviously, this longevity studies. [Rhonda]: Seen some of those, yeah. [Ray]: And I don’t fear it. I don’t think that it’s a bad thing. I’m doing it exactly when my body would be
producing it. [Rhonda]: Let me ask you again. So, the contrast shower was 10 seconds warm,
20 seconds cold, how many times…? [Ray]: End on cold. [Rhonda]: End on cold for two minutes. [Ray]: Ten times. [Rhonda]: Ten times, end on cold for 2 minutes,
right? [Ray]: Yeah. You know, I want you to get used to it because
that’s the conditioning part… [Rhonda]: I’m going to try this. Because I want to see if does my circadian
rhythm. [Ray]: And then dry off, get on bed, and at
that point, it’s…I don’t do the dark or I do dark or I do red lights. [Rhonda]: No blue lights. [Ray]: So, I do that, I don’t do screens. And then I wait 30 minutes and then I do the
melatonin. [Rhonda]: And then you do the melatonin. [Ray]: Sometimes, it’s a problem because it
used to be, like, after contrast shower I told you I’d hit the pillow and I’d fall asleep
in like seven minutes, you know. I mean, you get sleepy. And I usually like my melatonin, I use the
fast dissolves. So, I used to have them just laying down there,
ready to go. And I wake up in the morning, there they will
still be. I forgot it. But anyway, so the melatonin… And one of the things it did for me is it
completely cured secondary insomnia. It just… [Rhonda]: The contrast therapy and the melatonin? [Ray]: The combination of the two, yeah. [Rhonda]: And blocking it… [Ray]: I tried time release, it never worked,
I tried melatonin alone. I was doing the 1 milligram that did nothing. And if somebody just starts with 30 milligrams,
you’re going to feel hungover in the morning. So, you can’t just start there. Because, do you know what… Have you played with melatonin? [Rhonda]: I have. The largest dose I’ve done…I usually only
take melatonin if I’m trying to get over jetlag. And I’ve done 3 milligrams or if I’m traveling
somewhere I can’t sleep… [Ray]: So, for a normal person doing melatonin
and, in that point, if they go over the dose, the symptom is in the morning, they feel groggy
and they don’t want to wake up. [Rhonda]: I’ve heard about that, yeah. [Ray]: So, in the beginning, it’s just not
possible to do that. So, it’s just not possible to do that. But I built up a lot. And I’m getting all obviously at past 40,
my melatonin is falling off precipitously at this point that’s what all the studies
say. I’m doing it at the circadian time. The time on my brain would be releasing it,
probably is releasing it. And feel like at that point, I’m also I’m
entering a fasted state as well. You know, the dietary restriction my meals
were earlier in the day, so I’m so far past, I’m in the post-absorbed state at this point. And so, I just feel like it’s going to be
beneficial. And then, this study just came out. And unfortunately, I haven’t had time to dig
into the one that I posted for you, which is the, basically, SIRT1 and melatonin and
resveratrol all working together. So, they found a synergistic fact with melatonin,
resveratrol, and SIRT1. So, again, I see this clue once again of this
little trichotomy: sleep, dietary restriction, cold stress. [Rhonda]: Well, melatonin is a hormone, regulates
500 different genes, I mean, it’s 2.5% of the human genome. You know, it’s, like you said, it’s one of
the most important hormones that regulate brain antioxidants activity. You know, those studies have been shown [crosstalk] [Ray]: I mean, in ’90s there are a lot of
really, I know they were sort of fad diets books, but there are serious researchers too. They were all publishing all the little books
that with the small print that used to come out the way diet books used to be, you know. Before it was big money. And then to glossy stuff we see today. [Rhonda]: And you also mentioned that you
know, you’re at a point in your life where your melatonin is dropping precipitously. And that’s at least from the studies that
I’ve seen in like around 40 years, your pineal gland starts to make less and less melatonin. The other interesting thing is that most of
the melatonin made in the body is actually made in the gut. [Ray]: Gut…right the serotonin. [Rhonda]: Yeah, serotine gets converted into
melatonin. And my question is, what is it doing in the
gut? Like, what is it doing in the circulatory
system? I’m kinda interested in that. Like, I’d like to know. [Ray]: I think this is like…This paper really
made me excited because I had hypothesized these connections. And ran them by David. And we actually, we touched on it. We had, because of editorial limits on that
first paper, we had to sort of walk away a little bit from the sleep part. And we mainly focused on… [Rhonda]: It sucks. [Ray]: …the other stuff. But what it’s like. You know, it’s like, okay we got… [Rhonda]: Too many words, they make you trim
it down. [Ray]: Well, basically, but we’ve got it in
there but we had to do… We just said that people can adapt to sleeping
cool. These are like the aboriginal studies that
were done. And I think in the ’30s or whatever, where
they took literally refrigerated trucks in Australia, took the natives, who by culture
they sleep under 30-degree temperature. No covers, no blankets, they shiver all night. And they get perfect REM sleep. And yet, the Caucasian control, those guys
were just miserable and they were horrible. The same thing with the Lapps, you know. They could learn to sleep in these cold, just
on a little cot above the floor. The ice hut, and they were getting amazing
sleep even though it was cold. And they weren’t all blanketed, you know. So, what we know is we’re highly adaptable. That’s the point we’re making in the paper. And in fact, we know that we’ve now some studies
have come out in terms of metabolic rate and activity. The ones that were done in NIH, with [inaudible
01:55:27], people sleep better, I sleep better. Hospitals are cold not warm and there’s a
reason, you know. [Rhonda]: What I like to understand is…one,
I can’t sleep in the heat. That’s like, you know, I think a lot of people
are like that. But what I like to understand is why core
body temp… Core body temperature is absolutely under
a circadian rhythm, obviously melatonin plays a role in that. But I would like to understand why exactly. Why is it your body being cold, cooler make
you sleep? Like, why? You know, I like to present a mechanism. I’m curious. I want to know. And I’m trying to figure it out. I just started looking into it… [Ray]: I think it’s tied to the fact that
a drop in temp, half a degree, that the brain needs to see. You know, that’s half degree. You know, it’s really amazing… [Rhonda]: Hibernation? You know, that’s when a…in winter when they
sleep. [Ray]: Yeah. And if you think about it it’s really amazing
if you think about homeotherms versus poikilotherms. I mean, look at the difference in our regulatory
mechanisms and you look at how in the hell our bodies stay in a certain temperature. And another big leader in the thermoregulation
side, that’s a whole another branch of people, really interesting colleague that I’ve met. He’s been amazing, Ivanov, has done all those
stuff in regulation. Interestingly, our temperature is a result
of energy flux. And we don’t actually maintain body temperature. So, we’re actually not maintaining 98.6. It’s the net sum of what actually is going
on. And that’s actually kind of interesting. And he’s done amazing studies. When I was doing all the stuff with the energetic
stuff, his stuff was really, really incredible. But it just seems like this thing comes up
over and over that these things get connected. And if you think about it, in the last century
and that’s the subtitle of my book How Our Mastery of Food and Environment May Have Led
to Unintentionally Chronic Disease and Obesity. [Rhonda]: Super cool, Ray. This has been a very interesting conversation
we’ve had. We’ve covered a lot. [Ray]: Yeah, we did. [Rhonda]: We covered a lot. But… [Ray]: The room didn’t melt this time. [Rhonda]: Yeah, right? If people wanted to learn more about the science
you’re doing and the books you’re writing and the experiments you’re doing, anything
about Ray Cronise, where can they find you? What… [Ray]: Well, Google is easy, just Ray Cronise. It’s C-R-O-N-I-S-E. I guess you’ll slug that. Right now, for a short period of time, when
this is being… If you’re looking later, I have a crowdsource. “Our Broken Plate” is the title. It’s on Kickstarter. I love your support to try to do this. This is sort of proof that we can sort of
do this. And then, my regular website is hypothermics.com. But raycronise.com points to it. I probably be blogging a little less. I mean, literally, I blog once in the last
year, twice. I’m not one of the people that has to put
something up every week just to drive traffic because I don’t care. I just want to have something that really
to say that I put it up there. But go back and start and read, and you’ll
see actually where I was wrong. Because one of the things that you and I know,
but a lot of people don’t, science, you’re only learning when you’re wrong. And if your thoughts don’t evolve and if you
don’t change along with time, you’re probably not, like, pushing, hard enough. So, you’ll actually see my thinking evolve
on this. Some of the things we talk about today, I
go into more details. So that site. And then, sooner or later, I’ll probably have
“Our Broken Plate” and do a little work on there. So, I hope to use that as focus point to try
to pull together some of the philanthropy money that’s thrown and all the other stuff. [Rhonda]: What about social media? Do you…? [Ray]: Twitter. It’s @raycronise. I have an Instagram. I think my Instagram is Mr. ZeroG. You know, you can link to all those YouTube
channels all. And I’m not putting anything on there right
now. But you can link to all those at my Hypothermics
page. [Rhonda]: Awesome. Cool. Thanks a lot Ray for this. [Ray]: Great. It’s been fun. [Rhonda]: Cool.

100 thoughts on “Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan”

  1. Great data. A fun observation is how hyper he was and how courteous she was to let him go on and on and on and on with very little actual conversation. Rhonda observed his speech as we did — but it was a fine speech

  2. this is nothing new – what's fascinating is all the major religions have fasting in its tenets, way of life, science is just proving the benefits – there's just a lot of bias and disinformation in the world which is consumer driven

  3. August 2017 I did 8 days but I felt weak. Maybe it was social pressure and worry and stress?
    This coming august 2018 I’m going to try 14 days

  4. Water fasting doesn't fix anything. As Valter Longo found out it's the refeed that does the fixing. All that fasting does is trigger a potential repair mode. That's why you only need a five day water only fast to accomplish going into repair mode. Long fasts and I did a 33 day water only fast in 2014 and it was destructive. All the benefits (low blood sugar, lower blood pressure etc) all disappeared when the weight came back. I lost 48 pounds in 33 days of fasting and gained it all back in under 60 days plus 10 pound more for good measure. I'll never do it again. I also wasn't hungry, but I obsessed about food constantly and spent my days watching cooking shows, buying cookbooks and 3.5K in kitchen equipment in preparation for coming off the fast.

  5. I went on a 40-day water fast when I was 61. I could have gone longer but that was my target. The last week I was like a 9-monts pregnant woman: I just wanted to get it over. Two years later I am the healthiest person I know.

  6. This was so incredible. Dr. Rhonda love your approach this was riveting from beginning to end. Thought it would have been hilarious if you both busted out big macs like mid discussion just for shock value.

  7. Im so confused about IGF-1. Some say fasting increases it; others say it decreases it. Some say an increase is a positive; others say it negatively impacts health.

    Also, will having tea with lemon and stevia put me in a “fed” state?

  8. I wonder if long water fasts crank the adrenals so that the person seems like they're on speed. I don't think Ray blinked once in the video. I wonder if his IGF bounced the way it did because of his diabetes. Interesting n=1 discussion

  9. I think Ray is on a fasting high. I've been there after 72 hours of fasting which I think is one of the reasons he talks so much and doesn't allow Rhonda to speak very much! Good informative video. Thanks to you both!

  10. Rhonda.. let Ray rock.. nothing like researching with ‘skin in the game’, health not profit, global not obsessive specificity in learning. Great video. #language mattes.

  11. I wonder what his ketone levels are at 20 days of water fasting… must be around the 4.5's….

  12. I have recently being doing 13 to 14 hour fasts, from evening to late morning, and heard Rhonda say drinking coffee switches on the metabolic enzymatic processes. I dont drink coffee but my morning drink, i have warm mineral water with half a tea spoon of Celtic grey mineral sea salt and wondered if this would switch on the enzymatic processes that negate fasting?

  13. Whole food plant based diet, get some sun and skip some meals when you get fat. 1920s advice.

  14. How does such a lengthy fast affect gut enzymes that have been built up thru saturation? I’ve seen the rather stupid method of checking whether or not somebody is gluten tolerant by abstaining from gluten based foods for 30 days. Sure enough most people have a reaction when they reintroduce gluten foods. So does fasting for that length of time create dietary intolerances? And regarding blending and “drinking” your food – are you not taking out the amount of saliva you’d normally produce if you were chewing those foods?

  15. Imagine the amount of reduction of resources we'd be preserving from not having to nourish the growing live stock supply to match the demand… plus the reduction of animal suffering, land usage, and total greenhouse gases. I'm never gonna give up a good steak dinner but fasting like this can have more of an impact than your personal improvements of health.

  16. I've always, since I was around 20, tried eating foods very high in nutrients… i.e., basing my meals around so-called superfoods. For the past 1.5 years I've been doing a lot of fasting. Most weeks I do a 60 hour fast. I've also done some 5 day fasts. My gut level feeling is that we should balance out a diet VERY high in micronutrients (on our feasting days) with periods of fasting. I know this is subjective, but I can feel good things happening in my body when I fast for 60 hours, then resume eating, and eat the best foods in the world at that point…. very high nutrient superfoods like sardines, onions, garlic, mushrooms, pastured eggs, salmon, grass-fed beef, salads, fermented foods, and broccoli and other greens.

  17. Is there a comprehensive list of the food these people eat with maybe the nutrients they are eating them for? Searching on my own has not been very efficient and like Ray says everything that is easy to find is centered around fat carbs and calories. Rhonda has some great videos but they are all just a part of the big picture.

  18. I’ve morning fast till 12 noon for the second day and found a reduction in shoulder and back inflammation and didn’t have any hunger at all.Ate at 12 because I felt I should fasted for over 17 hours – amazing stuff

  19. It occurs to me they are both espousing eating to live whereas I find food is part of our social make up. The analysis is very sterile and critical for us to further the science and better understand what humans should consume to live longer and healthier. There are also 2 discussions that are confused in this discussion: dieting (eating to lose weight) versus just establish a healthy diet. Fascinating resource for own search for eating better but I also wonder, "do these people ever go out and have a good time?"

  20. Plants actually CAN yield significant amounts of healthy fats if they are in high nutrition with good soil and no pesticides or synthetic fertilizers in the system. See the "plant health pyramid". I get my exercise from farming… it is a great way to stay in shape and grow healthy food. 🙂

  21. I absolutely must Implement fasting into my lifestyle. I feel both an emotional dependence on food but also insulin resistance physiologically wrecks my body and mental state. Ironically, I feel most alive when I don't eat for about 36 hours.

  22. I wish you would talk more about cold therapy as well as saunas. A Iong time ago I lived by a river where I could jump into cold water year round, even while snow was on the ground. I'd just jump in and thrash frantically till my body started warming up to meet the cold, and then I'd get out after a minute or so. Then I could walk around in my wet bathing suit in 25 degree weather and not feel cold at all, rather I felt strong and energized. I said to myself way back then, "If I could do this every day for the rest of my life, I'd live to a hundred easy." Anyway, a video documentary was just put up on Youtube called "Swimming In Miracles" about a man with leukemia who decided to swim the entire length of the WIllamette River in Oregon (189 miles) to raise money for cancer. It took him 22 days, and the doctor tested him afterward and found the leukemia had disappeared. The documentary is all about the spiritual experience of learning how to flow like water and being grateful for every moment and so on, and that surely was a factor in his healing, but just briefly in passing it mentioned that, even in a wet suit, he was getting hypothermia. Several times a day, IIRC, he had to get out of the river and warm up in the sun to get out of the hypothermia. In other words, in addition to his spiritual lessons, he was getting short-term hypothermia every day multiple times a day for over three weeks. (My own river jumping didn't give me hypothermia, I was out too fast.) I just had to report this to you, so I looked for one of your videos that mention cold, there aren't many. I am surprised that not more research is done on it. In all the research on saunas, do they ever look for the difference between just taking a sauna and jumping from sauna or sweat lodge into a cold river? Anyway, if you are interested in the case do a Youtube search on "Swimming in Miracles."

  23. just don't give him any money for one of his projects. he will just spend it and not do the project. i would say got the t shirt but didn't even get that…

  24. I did not understand how come he did not think of eating sushi would increase his blood sugars due to all of the rice. and how come he did not realize that he should eat sashimi instead of sushi (only raw fish cuts without the rice)?!?

  25. I love listening to these smart nutrition longevity nerds geek out on all of these open minded, out of the box health and wellness concepts. I fell like I’m slowly becoming one of them. 🤓

  26. Based on Dr David Sinclair seminar, most good genes don't work after mid age. So need nmn or nr( as fuel), to make these genes response to exercise, or cold.

  27. I noticed you mentioned in a few times, mid age mice, got none benefits from workout, or cold. But can still get benefits from fasting.

  28. In fact, nutrition is spread out over the seasons, because various foods are only available in their season, except if dried or fermented. One meal a day should be enough for an adult ® as for hydroponics, the nutritional value depends entirely on the plantfood used. ¢ waiting for a more appropriate time to eat is an excellent idea. @ WHM since 2016.

  29. I don't hear Ray addressing the biolgical, studied male/female differences in using IF for __ reasons. Sure, there are women who are extra overweight, inflamed or suffering autoimmune disorders who benefit greatly. Then, there are the rest of women in the modern world saddled with some degree of body dysmorphia. For all the rest, IF is sexy lingo for anorexia. I GUARANTEE eating disorder crowd has latched onto this concept to further obscure their mental illness from friends and family.
    Honestly getting very tired of all the male proponents of IF who address a general audience with male-centric, unconscious language. It's mansplaining.

    Edit: and after watching this video that was supposedly about cold thermogenesis… And ended up being about nothing more than Cronise IFdeology… A crap ton of manterrupting also.

  30. 9:25 reading between the lines " I'm 51 (and male) so I'm done with reproduction " = I'm a man who's done with his libido. All it matters to me now is living as long as possible… with little libido. WTF?

  31. We do eat for social reasons, and for just personal entertainment. I realized this after starting intermittent fasting.

  32. We've done something similar to the hot/cold showers since I was a child. Where I'm from it's traditional to sauna year round. In the summer, we would go from a hot sauna right into the lake and then back into the sauna. In the winter, we would go from the hot sauna straight outside and have competitions as to who could stay outside the longest.

  33. Love the video but One point Ray has almost zero muscle mass is this a result of no resistance training or just how he is?

  34. I cant take advice from a guy who sits the way this guy does…hes like a child who got molested and is at the psychiatrist office

  35. Does something like a basic 15-hour intermittent fasting , with a 9 hour eating window, actually induce autophagy? Can you get rid of senescent cells this way or do you have to fast for several days??

  36. He is mistaken the human body's limits that allows us to live 30+ days without food IF WE HAVE TO,,, as a way to say "see food isn't important as we thought"

  37. I am a fan of your Dr. Patrick, and I am an intermittent faster, so was very keen for this episode. I must say this guest is very poor. He seems to not be able to provide answers to your actual questions, I think his comment that "sushi brings my diabetes back" is ridiculous, and I didn't get much out of his "eating from the right side of the food pyramid" description. It is especially poor how he stated at the beginning of the interview that he isn't interested in debating eating animal products versus plants, but then goes on to consistently promote eating plants. It would also have been interesting to push back against the idea that fiber is always good all the time, as I certainly don't think it is, and quite a few other people do not as well.

  38. I get that the format of this is a clinical conversation, and admittedly I'm probably just not learned enough, but I'm having trouble turning any of this into a basic plan of action. I get that its not 'bro fitness' or a diet plan per se. I'm just wondering if there's a bulleted list for those of us who are struggling through the latin. It's an honest question, I'm not poking fun at smart people. I'm glad Rhonda Patrick quests as dutifully as she does to avail others of scientific understanding. I have learned many things I didn't know previously. I just need a bit of help with summary, again, not asking to dumb it down. Just looking for the take-aways.

  39. As always, incredible interview Dr. Patrick! The depth of knowledge, with the addition of notes/explanations, beat any educational video on the net. Thank you for the incredible work!

  40. Dieters are boring narcissists. And the most boring are the ones who need to find a pseudo-scientific justifications.

  41. Im sure this guy is smart but he rambles on so much he is impossible to listen to, had to finish it early.

  42. 00:00:12 Ray Cronise shares how he feels on his 23rd day of fasting.
    00:01:40 Through a combination of fasting and cold stress, Cronise was able to lose weight and eliminate his type 2 diabetes.
    00:05:55 After 21 days of water fasting, all of Cronise's blood panels returned normal.
    00:09:07 Cronise reconsiders our perspective of meeting daily nutritional to a longer timeframe.
    00:14:04 The paradigm of being simultaneously overnourished and malnourished.
    00:20:40 Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians.
    00:22:34 Take care of your gut and your gut will take care of you.
    00:26:25 With Cronise's diet, one loses 0.6 to 0.8 lbs of fat per a day.
    00:27:23 What is metabolism and how do we measure it?
    00:30:50 We use to eat to support our activity, and today we are active to support our eating
    00:38:40 Meal timing to match nutritional needs and optimize health.
    00:44:17 Caloric restriction vs Intermittent fasting.
    00:48:30 Can food addiction be mistaken for hunger?
    00:59:48 Ray Cronise argues that we should not talk about protein, carbs, and fat but instead whole foods.
    01:08:44 Ray Cronise and Wim Hof's cold experience.
    01:15:22 Temperature contrast therapy may help one stay awake during the day and sleep better at night.
    01:23:40 Cronise surprisingly did not lose lean muscle mass during his fasts.
    01:28:42 Ray compares the similarities of cold stress and exercise.
    01:39:00 Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model
    01:39:00 Impairment of Rat Spatial Learning and Memory in a New Model of Cold Water-Induced Chronic Hypothermia: Implication for Alzheimer’s Disease
    01:41:25 Tips to using cold stress to get off the glycogen treadmill and increase fat oxidation.
    01:50:00 Anecdotes and fun facts about melatonin.

  43. Ray Cronise scammed $88,271.00 out of "investors" on gofundme…in 2015.If you go to the comments thread there you will see they never received any refunds and Gofundme doesnt care..

  44. With regards to the study mentioned at 1:39:57, it's fascinating why the protective effects occurred only in subjects that were exposed to cold stress in their early life (how early?) and those that did in midlife could not reap any such effects from exposure. It blows my mind.

  45. You're skipping over the ugly truth. People AREN'T eating the wrong foods. The fact is, there are VERY FEW foods in the average supermarket. The majority of items are processed textures infused with addictive chemicals designed to yield the manufacturers high profits at the consumer's expense. America only LOOKS affluent. The supermarkets offer an IMPOVERISHED selection of food.

  46. This video absolutely amazing!!! So grateful!!! I’m really interested in changing from keto to more fruit based- back and forth- to switch the burning mechanisms. The cold therapy is amazing info! Ty!!!!!

  47. cant believe idiots are still suggesting eating more fiber and plants and LESS meat and fat, exactly the reverse of what is actually healthy. Try it and see for yourself.

  48. I’d rather hear Rhonda Patrick speak. Ray looks like he needs some protein-he has no muscle tone and his skin looks flabby

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