GLUCONEOGENESIS on Keto Diet 🥩 Ketosis and Ketone Metabolism

GLUCONEOGENESIS on Keto Diet 🥩 Ketosis and Ketone Metabolism


gluconeogenesis explained the snake become chocolate cake hi I’m ginger I’ve been kita for almost six years and if these meetings are being useful to you please don’t forget to subscribe before you leave so you don’t miss the next one in this video we’re gonna look at the proper biochemistry of how the pathway of ketosis starts and which role gluconeogenesis play in it because I know there is a lot of misconceptions because I’ve heard them and I’ve said them for a very long time in this last six years until I finally started this year to start and dissecting the biochemistry at the cellular level mostly because I have to go back to school in September to do Biosciences so I needed to start understanding these things first things first though if you’re a patreon and you’re watching this thank you so much I made this video because you voted for it in July and that’s the reason why you’re watching it already and if you’re not a patreon this might be a month or so later and that’s because I try to thank my patrons with these little perks having Vitas in advance it’s one of the things and being able to vote on what I research and what I do as recipes it’s another one of those so if you would like to have those perks as well and have videos like these voted for by you and also in advance so to the general public release you can join patron – there is a link up here and one down in description below and if you decide to do so thank you so very much because that would support the entirety of this channel so here’s gonna be that not so stupid simple explanation but full explanation indeed of why whoever says that gluconeogenesis doesn’t matter in keto because it’s demand-driven does not quite understand that the demand actually starts when we enter ketosis gluconeogenesis is the precursor for us to be able to get into ketosis is the reason why the liver starts going crazy and the size that it starts making ketones which again it’s totally fine I was confused myself and I power rotted things that I used to hear for a long time myself and when you hear them being so popular those things like gluconeogenesis is demand-driven steak doesn’t become chocolate cake and those kind of things you just hear themself and then you just start repeating them although if we then look at the molecular mitochondrial level then we get to understand how the pathway of ketosis works and actually I’m gonna explain it here in detail but not so much down into the biochemistry level however if you want to see the entire full beautiful graph that you need to have patience for but ninja nerd science has gone through the entirety of how ketone production starts and how ketosis works basically and it’s fascinating to see from the point of view of someone that actually just studies biochemistry is not interested in Keita so it’s not interested in any of the camps pro protein pro fat anything like that it just explains how our cells actually start to work specifically the hepatocytes which are the cells of the liver so ketones how do we make them how do you use them for energy I’m glad you asked so they are neither of the two main forms of fuel that our mitochondria use for energy they are not fatty acids which would go better oxidation and they are not glucose which would become pyruvate which would go into oxidation as well turns out that ketones are indeed a third form of phew well besides fat and glucose that the mitochondria can use for energy and they are actually made from fat in the liver cells the effective size at all sites epiphyses and these once the liver makes ketones they are actually put back into the bloodstream so that the tissues that can actually use them for energy will pick them up and use them because funnily enough the liver can make but cannot use ketones the irony although the brain the heart kidneys and muscle in general actually favor ketones as a source of energy so that’s the reason why probably the liver puts it out now so I mean why why would the liver just be evil fuel away why does it even make it is it because it’s this generous organ that just gives away stuff is it because you notices that we don’t give it glucose so let’s be generous to all the other organs then maybe have trouble surviving as well cochon this is the part where I tend to anthropomorphize things know the leader is a little which in this sense sees the liver all around some glucose when he realizes there is not so much coming in it goes in this wrap the krebs cycle also better which is actually the process that happens in the mitochondria where we make energy ATP from fatty acids and glucose however the liver comes and disrupts it takes a little bit out of it because with that little bit it can make its own glucose via gluconeogenesis that little bit is oxaloacetate remember that all of these is happening before ketones are even seen from afar so the liver has taken oxaloacetate out of the Krebs cycle because it needs to make its own sugar because it feels like it’s too low what happens to the krebs cycle then well fatty acids and glucose need to go through the Krebs cycle to create ATP the energy that powers all the vital Condry on cells the Krebs cycle though has been disrupted so all the little bits from fatty acids and glucose which at this point is acetic away what do we do with that it cannot enter the Krebs cycle because you wouldn’t be able to finish it until vbi ATP what do we do with that acetic away that is just waiting and there is no krebs cycle for it anymore the liver decides that it can basically spare its recycling that’s an enzyme called a laser to two pieces of acetic away and those two as a few Quaid bonded together by a laser become a ketone acetoacetate to be precise which is one of the main two forms of keto that we have acetoacetate and the HD acetone that is the one that goes in the breath but fundamentally that’s the fundamental ketone that we make and we make it because again the liver decided that he needed for itself the oxaloacetate to make its own glucose and that just created an exuberance of acetyl Kawai which couldn’t go into the Krebs cycle so before it even gets there we get thiolase we bond them together and we give them to other cells that actually can use it again if you want to have more information on the detail to the enzyme of how acetic away becomes acetoacetate and then it becomes better intro toxin VHB and then acetone ninja nerd is that you want to go and walk sure because that’s step by step how it goes being biochemistry is a bit verbose and complicated and this is just the short version of that but fundamentally this is the reason why for ketones to be made the in deliver in the a better site at all and so therefore for us to be in ketosis the liver has to first decide that it didn’t have enough glucose so it needed to make its own and when the lever makes its own glucose that gluconeogenesis that’s the reason why gluconeogenesis actually is the precursor of ketosis and it’s not just the man driven or better it is the man driven for people who eat carbs it is the demand that the stars’ ketosis though when the lever is making his own glucose because again it just runs on glucose technically diacetyl Kawai at that point cannot even be transformed in ATP because again the krebs cycle was interrupted and we don’t go there so that’s the reason why acetic away at that point it’s the garbage of the lever because it cannot use it and it doesn’t care for using it so thank you deliver at that point could just trash the acetyl co a because anyway God is glucose doesn’t care but since God is oxaloacetate to make it so glucose fine let’s decide to be generous to the other tissues and basically offers the rest of the body cells it’s discarded asset yoke away bonded by an enzyme making it a ketone so basically we are eating the livers trash it’s recycling thankfully in the other cells those little precious ketones will get oxidized by the mitochondria they will go back in to becoming to acetic away and the cells will use them in the Krebs cycle which being to acetyl-coa is also the reason why ketones are considered very energy richer because to ask away means a lot of Krebs cycles going on so a lot of ATP coming out of it compared to just the oxidation of pyruvate or the bath oxidation of fatty acids but again cannot stress this enough if the liver wasn’t already making his glucose from gluconeogenesis you wouldn’t even take the oxaloacetate away from the krebs cycle and so leave the acetic away to be non utilized and therefore recycled an and transported s ketones into other cells so if the lever wasn’t getting into gluconeogenesis we wouldn’t be making ketones at all so this gluconeogenesis demand-driven absolutely the liver starts making glucose when there is too little around although the demand in this case is actually what starts ketosis and to be in ketosis and producing ketones we need the liver to constantly produce its own glucose because otherwise it would make ATP from acetyl Kawai not recycle it’s not sending it to other tissue in the form of ketones so this is the short maybe a little bit funny and entrepreneur finds version if you want the non anthropomorphize bits and actually the biochemical work and explanation you find all the links down in the description below to get your hand and highs into the krebs cycle the apat asides and how it all works together into this beautiful machine that is the human body I hope this video was useful and if it was please consider share it with your friends consider putting a thumbs up subscribe to the channel and if you can subscribe at that point please because you know because that way every time they one of my videos is out you will be notified and you can come and see me if you have any questions feel free to come to the Facebook group the Facebook page Instagram and I’ll be happy to try and find that the answer to all those thank you so very much for watching I will see you the next video 20 seconds club I really hope these helps and at the very least simple as I can express it the important thing is the biochemistry says so so it doesn’t matter how simple I make it sound they’re actually are all the sources that basically explain this is how the process of ketosis starts so it wasn’t a mistake saying it’s demand-driven but it was definitely a mistake to think that the general metabolism aside to ketosis because ketosis is the demand

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