Autophagy & Ketosis (are like Peas and Carrots)

Autophagy & Ketosis (are like Peas and Carrots)


we’re almost ready guys think we’re live alright we’re back on welcome back to another video it’s Mike Alonso here thanks so much for tuning in to this live stream sorry for the small delay getting started my daughter’s helping me out here and there’s a trouble with the autofocus but super excited that you’re here whether you hear live guys or you’re watching the replay today we’re going to talk about etaf adji this is a biochemical process that many of you are already familiar with but I want to give a little bit of insights and context and in regards to the ketogenic diet and also exercise I think you know we talked about etaf AG and my toe etaf AG micro etaf AG chaperone mediated etaf AG and today we’re gonna focus on macro esophageal and that’s the main mechanism through which exercise and a ketogenic diet and nutrient deprivation if you will that would be achieved through time restricted feeding intermittent fasting and or exercise and so forth the macro etaf adji is what’s going to be kind of that the main form or mode if you will modality of Vltava g that that’s pertinent to you so that’s where we’re going I do like to always check into the feed very quickly just to make sure that I’m like here and on and you all can see me because I’m not like pre recording this we’re doing this live so just give me one quick second and I apologize if you watch the replay all right we got quite a few on which is cool and I’m there I look very orange but what do you do so friends thanks so much for being here I look reasonably in focus which is hard to do when you’re self shooting so you know why talk about this on a Wednesday and what I’ve realized is if we create stories and we kind of learned through stories it may stick with you a little bit better so on Wednesdays you know my daughter gets out of school early she’s coloring right below here and she gets out at like 1 o’clock so we have to figure out stuff to do after school and so I took her on a bike ride in our neighborhood and I saw all the garbage cans out because the garbage men in the recite or I don’t think there’s any garbage women there could be I think it’s mostly men picking up the recycle bins in the trash I was like that’s so interesting that’s basically what a toff adji is it’s both our our our intracellular really etaf adji is going on macro tava gee that is that we’re speaking about today is occurring in the cytosol of the cell so you have your cell and you have your difference other components okay and so you know on Wednesdays what we do or everyday you guys probably do this to guys and gals wherever you are on the world what you do is you take your trash from your kitchen and your recycle and you bring it out to your driveway and then when the trash day comes you’re praying your big trash can out from you know that’s filled up with all the stuff the recycling things are thrown away your waste you put it on the street and that gets cleaned up that’s essentially a toff adji I in a nutshell okay now this is going on in your muscle cell your liver cell your immune system this is going on in your brain or I should say it should be going on in those different tissues but in various disease states you know everything ranging from autoimmunity from cancer from cachexia you know from you know insulin resistance obesity there’s dysfunctional etaf adji within fat cells that’s linked with obesity and obesity like fat cell inflammation so all these different things right so dysfunctional etaf if you actually an animal models when they when they splice out the so called etaf a genes which if you ever read the research it’s the capital a ATG the ATG genes there’s about 18 specific etaf adji genes and what I haven’t yet dove into and I’m hoping to explore in a new book that I’m working on is the single nucleotide polymorphisms the so called snips in etaf AG genes and I think maybe some people are more predisposed to sluggish etapa g pathways then those individuals might need to fast more often more frequently or and/or exercise more often and potentially might have issues with ketosis again this is just speculation I’m diving into the primary research now but etaf ajeeb aced upon a new animal model study that I’ll highlight right here is necessary is a necessary event where is it you guys are going to dig this one guys and gals you can dig this so it’s a right here so esophageal area biochemical event to stimulate hepatic and Riedl renal ketogenesis so that means sin ketone synthesis occurs within liver and the kidneys and seems that on a biochemical level at least in animal models at this point that Itachi is needed to stimulate ketogenesis in these different tissues and when etaf EG is blocked by likes affecting those so-called ATG genes those are the top of genes that these animals don’t make ketone so I think it’s really interesting to sort of think about so again just wanted to kind of throw that out there that’s one of the things that you know and I created a silly title of this video a toffee and Guiteau or like peas and carrots right now I think they really are like peas and carrots as forrest gump said nez what do you think of Forrest Gump remember she’s I know it’s an old movie with Tom Hanks you gotta check it out guys so going back to the analogy so what creates that basically your cells to kind of get rid of the trash in door recycle some of its components what are the steps needed to create that a tendon first of all in pause and preface where we’re going with this because so many of you have asked me fast other practitioners I get direct messages all the time I would say at least several times a day about hey Mike what breaks a fast is it okay to have coffee is it okay to have MCT oil is it okay to have branched chain amino acids is it okay to exercise on my fast what should how should I break my fast these are all amazing questions and I infer based upon the question and the people that are asking me this i infer that people are asking these questions because they’re actually really concerned about and hopefully my audios good yeah hopefully it’s not any echoey I wanted to make sure that I adjusted one thing and I’m thinking that I forgot but I’ll check the feed in a second people asking me these questions because what they’re trying to figure out is they’re trying to fast and they’re trying to kind of work around the fast so that it fits their lifestyle on their diet and you know cravings and things like that but not yes it sure that necessarily mitigate the potential health benefits garnered from the fast right and so people you know laughs it will Coffee kick me out of a fast I don’t think so I think really if we look at the mechanisms you know if we look at the cellular signaling components that kind of affect the Safa G in a toughie G signaling it really kind of starts with what let’s let’s talk about nutrition then we’ll talk about exercise separately because the signals are similar but they’re slightly different in exercise contexts in nutritional context but long story short in the nutritional context when individuals have glucose restriction and lack of growth signal stimulation so be lack of mTOR stimulation that triggers a toff adji and so you know free fatty acids floating around from the adipocytes releasing their own stored adipose tissue that’s not going to kick you out of ketosis so I think a small or I’m sorry I get doses at otha G so I think a small amount of you know a little bit of fat maybe a very small amount of MCT oil would not necessarily kick you out of a fast or would not necessarily you know ameliorate the health benefits that you want okay but what would affect and possibly slow down at otha G would be potentially any insulin signaling and so this is again we don’t have a lot of human clinical studies at this point that I know there’s there’s two exercise interventions where they tracked etaf AG genes so-called ATG genes and and other proteins associated with the toff is you signaling in overweight women and have shown that exercise in conjunction with a real food diet does increase at AA few G stimulation and so forth but we don’t have huge real Goods aid in humans to say well if you have this much butter or if you have this much meat or if you have bone broth or if you have chicken or you have whatever that that will or won’t or will inhibit or you know augment or enhanced esophageal we don’t yet know that so we have to kind of triangulate a little bit and this is where the haters Lane Norton and stuff is gonna say dude you’re just bro science hanging up over here I’m not bro science hanging up but because we don’t yet know all these mechanisms in humans because you know I guess I don’t know why I think maybe researchers are looking at this we do now know the mRNA transcripts that are increased when a toffee is stimulated but it seems like one way that you can inhibit a toffee for sure is to have glucose or to have insulin being stimulated okay that would be in a fasting context and so this was a this was one of those papers that that I wanted to kind of share with you on that alright so let’s get rid of that let me just check in to the feed and I know you guys watching the replay get a little bit annoyed when I do this so we’re on we’re here sound is perfect okay good I always worry about the sound because for those of you that have been with us on this channel for a while you know that we’ve had a fair amount of glitches with these live streams over the years when it comes to sound it only took me two years but I finally figured out hopefully uh-huh anyway all right so what will or what won’t kick you out of the fast okay let’s talk about coffee first this is a question people ask all the time well black coffee kick me on at the fast will black coffee blunt at ah Fuji Ynez please stop that it’s not so um she’s not complaints over and stuff like that so this is an important question I get this all the time I know you’re probably wondering yourself right now well again III don’t have three-dimensional glasses where I can see a toff eg jeans being turned on or turn off when you’re fasting but what I do know based upon the growth factors the nutritional factors that lead to the metabolic Cascades stimulated tofu gee it doesn’t seem probable that black coffee would negatively influence at ah fatigue now why would I say that well because the the the growth factors the metabolic stressors the metabolic signals that that inhibit esophageal are insulin and glucose and growth type factors so mTOR stimulation we’re going to talk about exercise in a minute so don’t be so scared of mTOR stimulation it’s really mTOR stimulation mediated through their so called a key tape a key Akt pathway the I think it’s called serine threonine phosphokinase pathway which is kind of an insulin mediated pathway so insulin and glucose stimulation protein stimulation those are factors that would potentially kick you out or that would not kick you out of a fast but that would maybe decrease the flux or the velocity if you will of etaf adji okay and again we don’t have randomized human political controlled trials here we’re talking about animal model studies so keep that in mind black coffee what it’s actually gonna do is it’s going to enhance fat tissue release of stored triglycerides and create more free fatty acids I think if anything that would enhance a tava gene that would enhance ketogenesis and again these are parallel synergistic pathways that would enhance the so called AMPK pathway okay so let’s just put it like this so it’s Hoffa G’s kind of the end goal right here there’s all these different targets above okay we have ampk we have PG C 1 alpha they kind of synergize on the so-called fox head box protein network fox o fox o3 is one of them and when that gets stimulated that triggers the the nucleus within your cell to then make these etaf G proteins okay so exercise time restricted feeding fasting glucose restriction carbohydrate restriction growth factor restriction so glucose deprivation and not having insulin surges those are all going to stimulate this nuclear receptor that’s gonna then kick off these etapa G proteins and again it’s like the analogy that I started this conversation with taking trash out of your house taking the recycling putting it into the big trash cans taken out to the street so the garbage people can pick up the recycling recycle the boxes and things from Amazon the order cardboard and so forth paper and then take out the trash the waste the things that you’re not going to use in your home or in this analogy within the cell and we can see when cells lose that ability to kick on this you know basically this recycling and waste system they become dysfunctional there’s aggregate proteins beta amyloid protein is one that we know in the brain that is associated and may contribute to the pathology and decline and neural functioning we know for example in in various tissues that I talked about the advanced we know in the liver the immune system now let’s just talk about the not all etaf a G is good nor is it all bad but it’s not something that you totally want upregulated all the time for example there is some connections between this pro-inflammatory pathway called nuclear factor Kappa beta many of you are familiar with this so if you have intestinal permeability if you have exposure to mold if you have exposure to lime even if you bump shoulder or something along those lines nuclear factor Kappa beta is going to be released this is the main kind of switch that turns on pro-inflammatory signaling pathways within the body okay and likewise taking fish oil taking curcumin taking vitamin D taking probiotics all these things down regulate NF kappa-b but it seems that NF kappa-b ana Tophet e are parallel pathways so cancer cells have figured out ways to adapt and evolve to influence their own etapa g signaling which can then guess what affect the growth and metastasis and things like that so keep that in mind so that’s kind of the there’s a u-shaped curve here some is good more is not always better so so you want to kind of keep that in mind but let’s talk about a toffee and exercise this is what’s really interesting and so we know that people that exercise sometimes they look younger visibly they might have better skin they might have reduced incidence of various diseases they might have better blood sugar regulation better insulin glucose tolerance more metabolic flexibility and it what’s interesting is just the adaptations that occur from exercise are etaf G mediated do you need to leave nothing going so she’s leaving can you shut the door please to lessen less background noise but I like to have a little buggy here alright so exercise is one way to stimulate at otha G and this is why you know it’s interesting to think about right you have this triad where we have your diet we have your feeding windows fasting windows and exercise obviously there sleep and there’s meaning purpose relationships you know all the environmental toxins and all these things right but I think it’s interesting that like we can get into ketosis by just changing our diet we can get into ketosis and in San mimic the so called fasting mimicking metabolism if you will through just exercise right so we know that people that are metabolically flexible even though they don’t aren’t low carb per se they their body can kick up ketones especially in the post-workout window they have great insulin signaling glucose tolerance and so forth right and then we also have the timer strips at feeding or fasting window elements so so we have this triad right and so we can tweak this and utilize it how we want and I think it’s important to understand this and so I think all of us listening kind the take-home message here is not so much will coffee kick me out of the fast well little butter kick me on the fast and whatever just to understand that anytime you’re kind of having a glucose or insulin or protein surge that is gonna send the signals to down-regulate etaf EG having t having coffee have a electrolytes maybe a small amount of MCT oil or a little bit of an exotic e tone if you really think you need it for the appetite you know suppression and things like that probably not that big of deal but – in terms of affecting etaf achieve but again we have exercise and exercise part of the weight and let me share with you one of the clinical studies here which is right here all right I would encourage you to read the study and by the way our patreon members you get access to the transcript of these videos and all the links to the studies and more that we talk about so just go to high intensity health comm for chest patreon or click the link below so I send those out about 24 hours after we do these live streams and so forth so if you’re interested in like diving deeper check it out if you’d like however interesting that triad so exercise is another tool it’s a stimulated tofu G and what’s interesting is is people that are exercisers and keto I’ve found generally myself many other friends in the space doing prolonged fast for them is hard you know going over 36 hours can be pretty challenging and you might think well that’s so easy the human body should be able to do that and you’re probably like yeah right but what if fatah Fiji’s already kicked up what if these gross signaling pathways are already being suppressed in the post-workout window because they’re being utilized right to recover from exercise so anyway it’s interesting to think about that like maybe if you’re getting your exercise in on a regular consistent basis you’re eating a low-carb high-fat healthy whole food drive diet and you’re doing your exercise maybe you don’t need to fast as much we’re often you can maybe compress your feeding window to twelve sixteen hours a day and still get many of the benefits that may be inactive people might only get after say 24 hours of fasting so I think it’s it’s neat because you know fasting although it’s it’s really great there’s a lot of health benefits to it fast every single money for 24 hours I do a quarterly you know 36 hour to 48 hour fast every fiscal quarter I think it’s great to really go longer than just the 24 to 36 hours I’d try to do every week but also when you’re exercising regularly you’re you’re ramping up that a tough G pathway so just think about it when you’re getting stronger and your deadlift or your squat or your pull-ups or your bench presses military presses if you do any of those major lifts when you’re getting stronger or your muscles are growing guess what’s working a toff ajit the adaptations that occur within the myocytes and and skeletal muscle is a toff g mediated guys so it’s pretty cool I think it’s pretty neat I don’t know about you too my two cents and friends these live videos are sponsored by our very own my Oh science nutrition one of the tools that we talked about before is berberine hydrochloride and so everything we’ve talked about up to now are is a summary of research and of course nutritional supplements and the things that I’m talking about I cannot cure prevent or treat diagnosed any disease but we do know that blood sugar health can be improved with berberine berline hydrochloride is one of the most researched natural compounds when it comes to supporting blood sugar health so we do have our berberine plus hydra it’s f the form of berberine is berberine hydrochloride with alpha lipoic acid so these are synergistic pathways links are below here we have our my o science storefront over on amazon and you can also go to my Oh science comm that’s my O science with an X my o X C ience comm be sure to use your promo code h-hi it’s just save 20% off your next order and again I found personally fasting and taking berberine really has an impact on blood sugar regulation and blood sugar health so keep that in mind obviously you don’t need any supplements to improve your health but supplements can help to supplement your healthy diet and lifestyle so I’m gonna get to some of your questions I’m sure you have a lot of questions here but again just to recap and summarize when it comes to kicking or kind of slowing down at off of you when you’re fasting you don’t want to have sugar you don’t have too much protein and what you really want is glucose restriction insulin restriction okay what about amino acids what about mTOR inhibition you know I don’t recommend if you’re fasting for esophageal I don’t recommend supplementing with BCAAs during the fast I recommend supplementing BCA’s before exercise and after exercise that’s when actually according to recent published research taking branch chain amino acids is gonna give you the best benefit and enhance exercise recovery and so forth is a round exercise now I know Gabrielle Lian and other people have talked about you need this muscle protein stimulus all the time and so forth but again according to the research when it comes to taking branched chain amino acids BCAAs particularly getting that bolus of leucine and we do offer clinically studied branched chain amino acids over at my Oh science but you know the leucine the bolus of that stimulates a muscle protein synthesis and the mTOR and studies show that around exercises when that’s most efficacious so keep that in mind having a little caffeine having black coffee having green tea these things are not going to necessarily imperative G if anything because they will enhance the fat cell lipolysis of stored lipids what that basically means lipolysis snipping stored fat and taking it out and freeing it from the fat cell putting it in the bloodstream if anything that will enhance a toff adji now the other big take home from this conversation is that ketosis may be necessary may be needed to enhance ketogenesis Inge and ketosis so keep that in mind again this is an animal model study that I shared with you earlier interesting to think about so let’s dive into some questions and just because we’re talking about science here and you probably want something more visually interesting to look at I’m gonna leave this diagram right here alright so thanks for being here guys it’s so fun and gals so fun to connect with you it’s always good that you’re here alright we got quite a few of you on which is super super awesome and also if you don’t if we’re not yet connected on Instagram yeah you can find me over at metabolic underscore Mike and Instagram the videos and images like you’re seeing right here I share this type of stuff all the time and Instagram so if you’d like to nerd out on science and so forth we can do that oh dude so spin all 1997 is sitting in their sauna right now BAM I love that so let’s talk about the Sun on heat stress I think this is interesting I think cold stress and heat stress can affect a toffee signaling again we don’t yet have human placebo controlled trials on that but I would imagine that due to the fact that it is a mild stress sure I need to look at the mechanisms of heat heat shock protein activation and the so called etaf AG gene so so-called ATG genes I’m sure there’s some crosstalk coalescence ER but you know from what I’ve read it’s more metabolic and nutrient stimulation so again the ampk the PG C 1 alpha affecting that Fox o3 protein and not that that kind of a protein Network then trips up or kind of kick starts if you will the so-called etaf AG genes and that’s what stimulates and makes proteins that kind of affect the the phagosome the and the auto phago for it’s really kind of funny that the vernacular the jargon associated with a Tophet ER there’s some interesting words in there eric says don’t give up fasting plus exercise gets easier than more often do it Eric you are on this so guys I’m starting something that maybe you can hopefully join me on it’s called metabolic Monday every Monday we’re gonna fast the entire day okay so what we do is basically we cut off dinner on Sunday by 7 p.m. whatever your time zone is and you don’t eat again if you want to if you want to do a 36-hour fast on Monday that’s fine but we’re gonna just fast for a at least 24 hours every single Monday for the rest of 2019 I would love to have you on board if you do please use the hashtag metabolic Monday on Monday when you fast now what’s the rationale and reasoning behind us well mondays are the first day of the week and we know that progress begets more progress momentum baguettes more momentum if you spend your Monday fiddling around in your email unproductive yeah you’re on social media things like that you’re probably gonna feel like crap about the rest of your week but if you’re fasting you don’t have to worry about food on new Monday you can hit a good work out and feel great about it and so that’s why I’ve been thinking about this for a long time and I’ve even made some videos on them on a Monday and called it metabolic Monday I think you guys recognize that but I’ve been doing this for the past couple Monday’s and I felt amazing the amount of I don’t have to you don’t have to think about food on a month like how could you even get so much but I got so much more done from a personal development audiobooks think articles just organizing taxes finances business you know content creation for this channel for you and it was amazing so I want you and I want to encourage you to join us on Monday so we’re cutting off the feeding window Sunday 7 p.m. y 7 p.m. because we want you to get to bed early and having a big full stomach full of food will affect your deep sleep and that will you know if you if you fast from 7 p.m. to 7 a.m. and you most people will get up around 7 or before and go to work you’re definitely going to be going to work in a ketogenic state and you know all the the different orexin a and different neurotransmitters that are upregulated to help humans become smarter when nutrient deprivation is kicked in will help you probably be more productive in your work so if your business owner if your stay-at-home mom whatever you do you will have a better day most likely all right so that’s a small neural side step wow we have a lot of questions here so starker hominoid says don’t do BCA’s during the fast yeah so that’s a good point so let me just drop in this visualization this visualization this picture this image of what I was trying to share with you guys wash it’s the thumbnail of this video and it actually shows it illustrates quite eloquently what we’re talking about here in regards to the in regards to the the various nutrients and so forth that are upregulated ok and so if you look there mTOR you know in terms of growth factor right so it’s hoffa g is more accountable and towards more growth and mTOR does inhibit mTOR signaling does inhibit otaku so just keep that in mind so having branched chain amino acids during a fast if you’re a paid athlete a paid bodybuilder and you’re really worried about maybe losing skeletal muscle mass and even that’s probably unlikely but if that is your scenario I understand it’s your business is your job maybe you want to take branch chain amino acids during your fast but for most people that are trying to just build it a little muscle burn fat you don’t need to worry so much about it okay so great great question there so Johnny says I tried a three day fast was so grumpy yeah totally get it totally understand I find sleep after 36 hours becomes a challenge that’s just me personally look I come in so many people I have friends that do these five-day fasts I think there ought it’s amazing right if you can do that but that’s it’s it’s tough right I mean I don’t I don’t know I think I think that being a little bit more consistent with shorter fast 24 36 hours more regular about that including exercise is going to be better long term so that’s just kind of my my personal perspective could be wrong in that I’m closing windows here and leave come on face book I get you out there all right just so someone here it says I hear a toffee and mTOR are triggered by exercise but opposites yeah that’s a that’s a great great point yeah so so interesting there is some kind of overlap though if you look at and I think this speaks to the tissue specificity of a toffee G is the toffee G smelling within the muscle tissue the same within the brain maybe maybe not right we know that different things like AMPK in the brain and specifically the hippocampus or the sorry the hypothalamus affects appetite differently than in the muscle tissue we know that acetylcholine stimulation or signaling within the heart has different effects on excitotoxin tori stimulation versus it in the brain right so I think what we’re going to probably see is that there’s tissue specific esophageal signaling and the skeletal muscle main respond in to the same signals for example mTOR maybe stimulatory of etaf G within the skeletal muscle but may downregulated off G within the brain and again so this is something that probably will be explored further but III it makes sense that there’s there’s tissue specificity in the toff ajit triggers but what we know across the board is starvation nutrient deprivation glucose deprivation insulin deprivation our global kind of stimulators of etaf G in a myriad of different cell and tissue types but it seems that maybe stimulation of muscle tissue via exercise may affect Tov G signaling possibly through mTOR which sounds kind of counterintuitive to what we just talked about but again this is just the studies that are coming out in humans and the kind of the mechanisms that are being elucidated in the animal model study so just keep that in mind again this tissue specificity keep that mind okay so but great question there this was from bum it–wait I think I’m hopefully I’m pronouncing your YouTube deal right so let’s see here gary says he’s late to the call this is when the best channels on YouTube dude very much appreciate those kind words if you guys do like this YouTube channel one way that you can kind of support us in a free way is go over to iTunes and just leave a little feedback it’s the same handle high intensity health and iTunes itunes unlike YouTube doesn’t that you can subscribe obviously to the audio version of this YouTube channel in 19th but their review based so I’m super grateful if you can leave that I would read all those so Steph says what this is I’m so glad so so Steph Casa Casas a hopefully I’m not watching your last name but Steph has asked a brilliant question what do you break it fast with and this this is something I want to address and I didn’t even think that we would get to okay okay so bear with me this is gonna sound a little bit crazy but when you pan intermittent fasting or prolonged fasting at least on your muscle tissue you get mildly insulin resistant you now you’re going hold that mic by come on I heard fasting is great for diabetes I heard it’s great for weight loss how can you become insulin-resistant from fasting and research has actually shown that beta-hydroxybutyrate the main ketone body guys guess what on a cellular level when it’s in high levels it induces in some resistance in muscle tissue again it’s this doesn’t mean that beta-hydroxybutyrate is bad it just means that it’s maybe because the muscles can be flexible it’s forcing the muscles to utilize more fat for fuel which is a good thing for fat loss and it’s freeing up glucose for the obligate cells like the red blood cells like the retina various neurons are obligate glucose utilizers they can’t utilize ketones or fatty acids so this is a great question going back from Steph and she says what should I eat after I’ve been fasting I can’t remember so that your muscles because of the high levels of ketones might be mildly instant resistant so basically you want to break your fast with protein and fat okay I think that’s important to keep in mind and it’s also important to understand the intimate fasting studies versus continuous energy of restriction studies that is like low calorie versus intermittent fasting have shown that on refeed days that would be on non fasting days people that do alternate day fasting or intermittent fasting tend to overeat so you want to keep that in mind you’re probably going to naturally want to overeat I want to make sure to break your fast with quality protein so this can be plant-based protein this can be animal flesh whatever your thing is that’s not my prerogative it’s whatever floats your boat and whatever you know you can tolerate and digest so like I personally when I break my fast I’ll have a little bit of burn broth or meat we cook a lot of meat in bone broth and all that kind of can hate to use this analogy but kill two birds with one stone using the crock-pot because after you cook your bone-in meats you can take it out and get the broth and you know get the great growth factors and collagen peptides and all that from the broth and so that’s what I generally will break it fast with or eggs those are great to avocado i we make a lot of nut milks and nut breads there keto friendly obviously around here so there’s the few things that I recommend that you break you fast with but this that’s just such a brilliant question so here’s what you don’t want to rake it fast with is carbohydrates because your body although you’re in agloe glucose states your muscle tissue is mildly and some insulin resistant due to the fast again to kind of help the red blood cells in the obligatory cells that are rely upon glucose for fuel you want to give you know that’s kind of one of the adaptive responses that occurs metabolically during a fasted state and so you you you don’t want to have carbs in the in the post fast window sounds counterintuitive I know maybe but kind of makes sense and again so this is why I like fasting and etaf G and keto are like peas and carrots right there they’re like bread and butter they’re like peanut butter and jelly they really lend well together so let me just see here what else we have what else we got thanks for being here guys I’m gonna get to a few more questions and then we’re gonna have Abdur with the fam eating with families real important friends so what else sooo we got JG Lee says perhaps you’re in ketosis more research will come on is it future is it Tov G yeah so I think I think more research will come out about kind of the connections and the you know maybe if your ketone levels are X then that means there’s this theory or not of atop G’s signaling really good really good questions there Eric Williams says just dry fasting help lose skin from losing a lot of weight yeah so Eric you want to check out the video that I did with Jason Fung it was about in 2016 so if you just type in Jason Fung intermittent fasting I think the thumbnail says something about muscle loss in the thumbnail fasting and muscle loss and click on that he talks a lot about the loose skin and and fasting so great question from spin all 1997 they say is red meat or poultry better protein source I think red meat and so as you all know or maybe you don’t know we have two pigs to hogs we have just like 16 chickens three turkeys what I found first of all this is why I like red meat and the cow gods the lamb gods they’re gonna hate me the elk gods are gonna hate me but first of all you know those type of animals they’re supporting more mass right chickens are very light so you can pick them up with one hand my daughter who’s six can pick up two at a time they’re very small and they are quick so they’re fast which they’re moving around but most of the animals that you all are gonna be eating from the grocery store because probably you’re not going to raise back our chickens and start slaughtering them if you do I mean it’s a better protein source and buying store-bought chicken most Robot Chicken white meat they never see sunlight because they’re in an indoor enclosed container they don’t have fresh air they’re staying on concrete their microbiomes are crap so I don’t think it’s a high quality meat look I know it’s generally white meat is cheaper than say red meat I think red meat is a higher quality meat I do the fact that even if you’re getting feedlot cattle they have so much mass cattle or heavy so just by that they have to have a certain amount of like you know just basic tonal skeletal muscle to hold them upright they have to be able to move around all that weight so I think it’s just better quality protein I think it’s it’s darker it’s more enriched in mitochondria that’s right that’s just my my two cents and personally like you know I’ve shared this on the channel we talked about stayin efforting about this you know when my bodybuilding friend got me into low carb high fat diet in 2002 you know one of the things that I switched was getting off the egg whites and getting off lot of the boneless skinless chicken breast and getting a lot more red meat in and back then I’ll cook it on this George Foreman grill I mean it was really unhealthy how I was preparing it but I noticed that I was able to like maintain more strength to develop lean muscle mass by switching to red meat again so I’m sorry cow gods I’m sorry elk gods and venison sheep you know all that but around here so in our house you know we eat a lot of lamb I just like the taste of lamb and I find that in our area there’s a lot of lamb and generally people don’t like lamb but you seeing beef or chicken or and so we can get the bone-in lamb for very affordable and it’s wow it’s a green grass fed and everything like that obviously you know we do butcher box provides a great product so you can get access to that if you don’t have local farmers and things like that go to butcher box comm for josh h IH you get $20 off your first order so there’s a lot of different options but I strongly suggest getting to know a local farmer just getting something in your area so it’s not being shipped around and you know it’s fresh hopefully you know how they’re treating the animals that they’re getting sunlight I mean that’s the thing with cattle is they’re so big so heavy they have a lot of gas that they they fart a lot with methane and everything they need to be outside so at least they’re seeing sunlight they may be eating skittles and may be eating soy and corn but at least you’re outside the chickens are eating all that crap plus you’re inside they never see sunlight and by the way chickens love the Sun when it’s sunny here in Seattle my chickens are always in the Sun like just sunbathing they call dust-bathing so my two cents guys on what’s better chicken or beef some ones that read me a bunch of people are talking about that Sookie doe mama says clean house is my house dirty maybe so yeah you guys have so many great questions everyone’s like yeah you guys dig in the metabolic Mondays let’s see fasting America diet is for people there are some swear words there so I really really appreciate you guys tuning in then like I said you know one of the best natural tools that can help to kind of kickstart your fast is exercise you can’t depleting that glycogen check out the interview we did with Ben Beckman also berberine hydrochloride again we’re not treating care and preventing any diseases here we’re just helping to improve your health berberine hydrochloride we have a new product it’s berberine hydrochloride the form that is the most efficacious also with alpha lipoic acid and it’s kind of in the B Phi B vitamin family and and those two paths those two kind of mechanisms by which those two natural products work is by stimulating the so called AMPK pathway they’re synergistic with stimulating ketosis and also stealing top G and as a listener of this channel as a subscriber you can save 20% by going to my own science comm that’s my science for the next my LXE ie and see.com we also have all these products on Amazon as well use the promo code HOH and save 20% off your next order and with that friends we’re gonna part ways thank you so much for tuning in sorry if I didn’t get to your questions there was a lot of questions a lot of comments I am always grateful that you’re here if you’re listening right now and you like this style video please hit that like button you can always share this with a friend or family member someone that may benefit if they like the science and if we’re not yet connected on Instagram dude let’s get connected send me a DM over on instagram metabolic underscore Mike say Mike I just turned in to the live stream what’s happening I always reply to the to the DMS like connected with you like to know what you think is important and I hope you have a great day got some new podcasts coming to you later on this week I’m gonna send off guys and gals thanks for being here we’ll catch you on the next livestream peace

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